| Drug Name |
Divalproex sodium |
| Drug ID |
BADD_D00696 |
| Description |
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton.[A178051] It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects of khelline when he found that all of his samples, dissolved in valproic acid, exerted a similar degree of anticonvulsive activity. It first received approval on February 28, 1978 from the FDA under the trade name Depakene.[L6190]
Since then, it has been investigated for neuroprotective, anti-manic, and anti-migraine effects. It is currently a compound of interest in the field of oncology for its anti-proliferative effects and is the subject of many clinical trials in a variety of cancer types. |
| Indications and Usage |
For treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures associated with Lennox-Gastaut syndrome. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
N03AG01 |
| DrugBank ID |
DB00313
|
| KEGG ID |
D00304
|
| MeSH ID |
D014635
|
| PubChem ID |
23663956
|
| TTD Drug ID |
D03LGY
|
| NDC Product Code |
55111-530; 70518-1749; 65862-959; 0904-6615; 55111-529; 68084-782; 63187-742; 65162-755; 71610-032; 68788-7183; 71335-1883; 50090-4409; 68084-776; 57237-047; 64679-724; 51079-766; 29300-138; 55154-5633; 0615-8326; 70518-2527; 50090-3616; 55111-534; 71610-031; 29300-380; 70518-0312; 50090-2795; 68084-313; 68001-472; 68001-473; 63629-4278; 51655-365; 70518-0282; 0615-8237; 55154-2336; 71335-0008; 70518-2036; 70518-2626; 67296-1677; 0615-8329; 66064-1001; 29300-381; 70518-2665; 23639-0001; 0074-6114; 57237-048; 68180-265; 55111-532; 0832-7124; 55700-938; 68071-4102; 68001-106; 0904-6861; 68382-134; 70518-3055; 70518-0463; 55154-4759; 65862-594; 62756-797; 0074-7325; 70518-1759; 65841-639; 68382-133; 68382-032; 50268-258; 70518-2357; 71610-157; 70518-1558; 0074-7402; 16714-485; 65841-637; 70518-3183; 0074-6214; 51079-767; 68382-033; 50090-3416; 55700-939; 70518-2513; 55111-533; 0832-7123; 71610-249; 70518-1897; 71610-289; 0074-6215; 48433-125; 71610-205; 48433-126; 71610-311; 68382-106; 65862-402; 68180-260; 70518-3364; 70518-2003; 0904-6363; 65862-975; 68788-7177; 55154-4679; 71610-201; 63187-743; 68001-474; 0904-6364; 65841-638; 70518-1138; 62756-798; 63629-4698; 65841-634; 17856-0262; 65862-595; 68788-8145; 55154-7640; 68108-0234; 16714-484; 68084-415; 27241-115; 68180-261; 50090-4187; 0378-0472; 0904-6860; 55111-531; 70518-1781; 65977-0114; 68382-031; 65841-635; 67296-1635; 0832-7122; 70518-1456; 49452-2542; 0615-8377; 55154-7145; 0074-7327; 50090-4861; 0074-7401; 60687-211; 17349-0011; 68001-105; 50090-5843; 64679-725; 55111-875; 58118-0040; 50090-5783; 70518-2510; 68925-0005; 68788-8085; 71610-030; 68180-267; 70518-1758; 65162-757; 70518-1556; 62756-796; 47621-006; 0615-8328; 0378-0473; 70600-016; 70518-0374; 43353-547; 17856-0109; 0074-3826; 70518-2674; 57237-106; 29300-140; 49169-1028; 65841-636; 0615-8327; 68180-266; 50090-4737; 61919-648; 29300-139; 50090-2007; 55154-3552; 0615-8376; 65862-403; 0615-8330; 0074-7126; 50090-5842; 68084-310; 0074-6212 |
| Synonyms |
Valproic Acid | 2-Propylpentanoic Acid | 2 Propylpentanoic Acid | Divalproex | Depakene | Convulsofin | Depakote | Dipropyl Acetate | Divalproex Sodium | Semisodium Valproate | Vupral | Valproic Acid, Sodium Salt (2:1) | Propylisopropylacetic Acid | Ergenyl | Magnesium Valproate | Valproate | Valproate Sodium | Sodium Valproate | Calcium Valproate | Valproate Calcium | Depakine |
