Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dimethyl fumarate
Drug ID BADD_D00680
Description Dimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera.
Indications and Usage Used in multiple sclerosis patients with relapsing forms.
Marketing Status Prescription
ATC Code L04AX07
DrugBank ID DB08908
KEGG ID D03846
MeSH ID D000069462
PubChem ID 637568
TTD Drug ID D0A7MY
NDC Product Code 64406-007; 68180-776; 63759-0027; 68180-777; 69097-322; 59651-061; 70710-1205; 43598-429; 51407-441; 69238-1318; 82245-0105; 62207-003; 16729-416; 31722-657; 67877-555; 69238-1626; 43598-430; 58159-013; 69539-043; 16729-417; 31722-658; 54864-663; 64406-006; 55111-975; 70710-1416; 69238-1319; 71348-100; 10920-598; 65015-844; 0093-9218; 59285-003; 62512-0074; 62579-301; 50379-0013; 24979-127; 24979-129; 76055-0026; 70771-1532; 71348-101; 69037-0012; 55111-997; 24979-128; 64406-005; 69097-323; 69667-1229; 69539-240; 70710-1204; 0093-9219; 31722-680; 69539-042; 49812-0255; 0378-0396; 66577-043; 69097-552; 68180-778; 70771-1531; 70771-1530; 0378-0399; 51407-442; 50090-5288; 62675-0393; 67877-556; 66039-901; 67877-557; 62756-178; 71348-102
Synonyms Dimethyl Fumarate | Fumarate, Dimethyl | 2-butenedioic acid, (2E)-, dimethyl ester | Dimethylfumarate | BG 00012 | 00012, BG | BG00012 | BG-00012 | Tecfidera | FAG 201 | 201, FAG | FAG201 | FAG-201 | Fumaderm | BG 12 compound | 12 compound, BG | compound, BG 12 | BG12 compound | compound, BG12 | BG-12 compound
Chemical Information
Molecular Formula C6H8O4
CAS Registry Number 624-49-7
SMILES COC(=O)C=CC(=O)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Conjunctival haemorrhage06.07.01.001; 24.07.05.001--Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Conversion disorder19.24.01.0010.003667%Not Available
Coordination abnormal17.02.02.0040.014669%Not Available
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Costochondritis15.07.03.0010.001834%Not Available
Cough22.02.03.001--
Crohn's disease10.02.01.005; 07.08.01.0150.015586%Not Available
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.005--Not Available
Cryptorchism21.15.01.001; 05.05.02.002; 03.03.01.0010.001834%Not Available
Cryptosporidiosis infection07.19.03.002; 11.06.02.0010.002751%Not Available
Cushing's syndrome24.08.04.001; 19.07.03.002; 14.11.01.007; 05.01.01.001--Not Available
Cyanosis22.02.02.007; 02.01.02.002; 24.03.01.007--
Cyst16.02.02.002; 08.03.05.001--Not Available
Cystitis20.03.02.002; 11.01.14.0010.039424%
Cytomegalovirus infection11.05.01.002--
Deafness04.02.01.0010.012836%Not Available
Death08.04.01.001--
Decreased activity19.11.01.002; 08.01.01.006--Not Available
Decreased immune responsiveness10.02.01.0410.005979%Not Available
Decreased interest19.15.02.0040.004584%Not Available
Decubitus ulcer23.03.11.0060.021087%Not Available
Defaecation urgency07.02.04.0010.004584%Not Available
Dehydration14.05.05.0010.165030%
Delirium19.13.02.001--
Dementia19.20.02.001; 17.03.01.0010.014669%Not Available
Dementia Alzheimer's type19.20.03.001; 17.03.06.001--Not Available
Demyelination17.16.02.0010.002751%Not Available
Dental caries07.09.01.001--
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