Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Difluprednate
Drug ID BADD_D00667
Description Difluprednate is a topical corticosteroid indicated for the treatment of infammation and pain associated with ocular surgery. It is a butyrate ester of 6(α), 9(α)-difluoro prednisolone acetate. Difluprednate is abbreviated DFBA, or difluoroprednisolone butyrate acetate. It is indicated for treatment of endogenous anterior uveiti.
Indications and Usage For the treatment of inflammation and pain associated with ocular surgery.
Marketing Status Prescription
ATC Code D07AC19
DrugBank ID DB06781
KEGG ID D01266
MeSH ID C015808
PubChem ID 443936
TTD Drug ID D01ZOG
NDC Product Code 49803-002; 46439-8738; 26251-0003; 46439-8739; 69097-341; 76282-708
Synonyms difluprednate | ENV905 | C.M.9155 | Epitopic
Chemical Information
Molecular Formula C27H34F2O7
CAS Registry Number 23674-86-4
SMILES CCCC(=O)OC1(CCC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C(=O)COC(=O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperaemia24.03.02.002--Not Available
Hypotension24.06.03.0020.000965%
Intraocular pressure increased13.07.04.0020.019778%Not Available
Iridocyclitis06.04.03.001--Not Available
Iritis10.02.01.022; 06.04.03.002--Not Available
Keratitis06.04.02.0020.000965%
Keratopathy06.06.03.0070.001930%Not Available
Lacrimation increased06.08.02.0040.000965%
Macular oedema06.04.06.005--Not Available
Ocular hyperaemia06.04.05.0040.003377%Not Available
Optic nerve injury17.04.05.008; 12.01.16.001; 06.11.02.001--Not Available
Panophthalmitis06.04.05.005--Not Available
Photophobia17.17.02.006; 06.01.01.0040.000965%
Posterior capsule opacification12.02.02.002; 06.06.05.001--Not Available
Pregnancy18.08.02.004--Not Available
Pruritus23.03.12.001--
Punctate keratitis06.04.02.0030.001930%Not Available
Rash23.03.13.0010.001447%Not Available
Retinal tear12.01.04.014; 06.09.03.0100.000965%
Scab23.03.03.004--Not Available
Skin striae23.01.05.002--Not Available
Teratogenicity12.03.01.032; 03.02.01.004--Not Available
Uveitis10.02.01.023; 06.04.03.0030.000965%
Vision blurred17.17.01.010; 06.02.06.0070.008201%
Visual acuity reduced17.17.01.011; 06.02.03.0010.002412%
Visual field defect17.17.01.001; 06.02.07.0030.001930%Not Available
Visual impairment06.02.06.0080.003377%Not Available
Weight increased13.15.01.006--
Hypoacusis04.02.01.0060.001447%
Foreign body sensation in eyes06.01.01.006--Not Available
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