Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Deferiprone
Drug ID BADD_D00595
Description Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA approved on October 14, 2011.
Indications and Usage Deferiprone is indicated in thalassemia syndromes when first line chelation agents are not adequate to treat transfusional iron overload.
Marketing Status Prescription
ATC Code V03AC02
DrugBank ID DB08826
KEGG ID D07416
MeSH ID D000077543
PubChem ID 2972
TTD Drug ID D0N0OU
NDC Product Code 10122-101; 10122-103; 0054-0576; 52609-0006; 17349-0023; 10122-104; 0054-0711; 10122-100; 51672-7502; 52609-4502; 51672-4196; 52609-0007
Synonyms Deferiprone | 1,2-Dimethyl-3-hydroxy-4-pyridinone | 1,2 Dimethyl 3 hydroxy 4 pyridinone | DMOHPO | 1,2-Dimethyl-3-hydroxypyrid-4-one | 1,2 Dimethyl 3 hydroxypyrid 4 one | 3-Hydroxy-1,2-dimethyl-4-pyridinone | 3 Hydroxy 1,2 dimethyl 4 pyridinone | HDMPP | 1,2-Dimethyl-3-hydroxypyridin-4-one | 1,2 Dimethyl 3 hydroxypyridin 4 one | Ferriprox
Chemical Information
Molecular Formula C7H9NO2
CAS Registry Number 30652-11-0
SMILES CC1=C(C(=O)C=CN1C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.003--Not Available
Papilloedema17.07.02.004; 06.09.02.002; 24.03.07.001--
Parotid gland enlargement07.06.03.001--Not Available
Periorbital oedema23.04.01.002; 10.01.05.010; 06.08.03.017--
Pharyngitis22.07.03.004; 07.05.07.004; 11.01.13.0030.008747%
Photosensitivity reaction23.03.09.003--
Pneumonia11.01.09.003; 22.07.01.0030.017494%Not Available
Pruritus23.03.12.001--
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pyrexia08.05.02.0030.043734%
Rash23.03.13.001--Not Available
Rash pustular23.03.10.003; 11.01.12.002--
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Seizure17.12.03.001--
Sepsis11.01.11.0030.003803%
Serum ferritin increased13.11.01.0260.008747%Not Available
Sickle cell anaemia with crisis01.04.02.0010.014578%Not Available
Sinusitis22.07.03.007; 11.01.13.0050.005831%
Skin disorder23.03.03.007--Not Available
Somnolence19.02.05.003; 17.02.04.0060.008747%
Subcutaneous abscess11.01.12.007; 23.09.04.003--Not Available
Tachycardia02.03.02.0070.005831%Not Available
Thrombocytopenia01.08.01.0020.008747%Not Available
Thrombocytosis01.08.02.001--Not Available
Torsade de pointes02.03.04.005--Not Available
Trismus17.01.03.004; 15.05.04.004--
Upper respiratory tract infection11.01.13.009; 22.07.03.0110.005831%
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