Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Deferiprone
Drug ID BADD_D00595
Description Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA approved on October 14, 2011.
Indications and Usage Deferiprone is indicated in thalassemia syndromes when first line chelation agents are not adequate to treat transfusional iron overload.
Marketing Status Prescription
ATC Code V03AC02
DrugBank ID DB08826
KEGG ID D07416
MeSH ID D000077543
PubChem ID 2972
TTD Drug ID D0N0OU
NDC Product Code 10122-101; 10122-103; 0054-0576; 52609-0006; 17349-0023; 10122-104; 0054-0711; 10122-100; 51672-7502; 52609-4502; 51672-4196; 52609-0007
Synonyms Deferiprone | 1,2-Dimethyl-3-hydroxy-4-pyridinone | 1,2 Dimethyl 3 hydroxy 4 pyridinone | DMOHPO | 1,2-Dimethyl-3-hydroxypyrid-4-one | 1,2 Dimethyl 3 hydroxypyrid 4 one | 3-Hydroxy-1,2-dimethyl-4-pyridinone | 3 Hydroxy 1,2 dimethyl 4 pyridinone | HDMPP | 1,2-Dimethyl-3-hydroxypyridin-4-one | 1,2 Dimethyl 3 hydroxypyridin 4 one | Ferriprox
Chemical Information
Molecular Formula C7H9NO2
CAS Registry Number 30652-11-0
SMILES CC1=C(C(=O)C=CN1C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypersensitivity10.01.03.003--
Hypersplenism01.09.02.002--Not Available
Hypertension24.08.02.001--
Hypospadias21.15.01.003; 20.07.04.001; 03.03.01.005--Not Available
Hypotension24.06.03.0020.014578%
Hypotonia15.05.04.008; 17.05.02.002--Not Available
Immune system disorder10.02.01.001--Not Available
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Infection11.01.08.0020.002282%Not Available
Intracranial pressure increased17.07.02.002--Not Available
Jaundice09.01.01.004; 01.06.04.004; 23.03.03.030--Not Available
Leukopenia01.02.02.0010.011662%Not Available
Liver function test abnormal13.03.01.0130.005831%Not Available
Lymphopenia01.02.02.0020.008747%Not Available
Metabolic acidosis14.01.01.003--Not Available
Muscle spasms15.05.03.0040.005831%
Myalgia15.05.02.0010.008747%
Myelodysplastic syndrome16.01.04.001; 01.10.04.0010.001521%
Myositis15.05.01.001--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.0010.023325%
Nephropathy20.05.03.001--Not Available
Nervous system disorder17.02.10.001--Not Available
Neutropenia01.02.03.0040.078721%Not Available
Neutrophil count decreased13.01.06.0100.011662%
Nystagmus17.02.02.006; 06.05.02.006--
Obsessive-compulsive disorder19.06.05.002--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Optic neuritis06.04.08.002; 17.04.05.001; 10.04.10.002--Not Available
Osteoarthritis15.01.04.001--Not Available
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