Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Daunorubicin
Drug ID BADD_D00590
Description A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.
Indications and Usage For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults. Daunorubicin is indicated in combination with [cytarabine] for the treatment of newly-diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC) in adults and pediatric patients 1 year and older.[L32843]
Marketing Status approved
ATC Code L01DB02
DrugBank ID DB00694
KEGG ID D07776
MeSH ID D003630
PubChem ID 30323
TTD Drug ID D01XWG
NDC Product Code Not Available
UNII ZS7284E0ZP
Synonyms Daunorubicin | Daunomycin | Rubomycin | Dauno-Rubidomycine | Dauno Rubidomycine | Rubidomycin | Daunoblastin | Daunoblastine | NSC-82151 | NSC 82151 | NSC82151 | Cerubidine | Daunorubicin Hydrochloride | Hydrochloride, Daunorubicin
Chemical Information
Molecular Formula C27H29NO10
CAS Registry Number 20830-81-3
SMILES CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal pain07.01.05.005--
Gingival bleeding24.07.02.010; 07.09.07.001--Not Available
Haemoptysis24.07.01.006; 22.02.03.004; 02.11.04.009--Not Available
Haemorrhoids24.10.02.002; 07.15.03.001--
Hallucination19.10.04.003--
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Hepatomegaly09.01.05.001--Not Available
Hiccups07.01.06.009; 22.12.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkinesia17.01.02.008--Not Available
Hyperpyrexia08.05.02.002--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hyperuricaemia14.09.01.003--
Increased appetite08.01.09.027; 14.03.01.003--Not Available
Infection11.01.08.002--Not Available
Influenza like illness08.01.03.010--
Injection site inflammation12.07.03.009; 08.02.03.008--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Leukopenia01.02.02.001--Not Available
Liver disorder09.01.08.001--Not Available
Local reaction08.01.03.012--Not Available
Loss of consciousness17.02.04.004--Not Available
Lung infiltration22.01.02.004--Not Available
Lymphadenopathy01.09.01.002--Not Available
Malaise08.01.01.003--
Melaena07.12.02.004; 24.07.02.013--Not Available
Meningitis17.06.03.001; 11.01.03.001--
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ADReCS-Target
Drug Name ADR Term Target
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