Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dapagliflozin
Drug ID BADD_D00578
Description Dapagliflozin is a sodium-glucose cotransporter 2 inhibitor indicated for managing diabetes mellitus type 2.[A6757] When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose resorption in the proximal tubule of the nephron and causing glycosuria.[A6757] Dapagliflozin was approved by the FDA on Jan 08, 2014.[L6034]
Indications and Usage Dapagliflozin is indicated for adjunct management of glycemic control in patients with type 2 diabetes mellitus, in combination with diet and exercise.
Marketing Status Prescription
ATC Code A10BK01
DrugBank ID DB06292
KEGG ID D08897
MeSH ID C529054
PubChem ID 9887712
TTD Drug ID D01TNW
NDC Product Code 17228-6205; 50090-3482; 14501-0028; 55154-6932; 59285-012; 66529-0003; 54921-621; 55111-987; 69037-0027; 65727-073; 12783-1428; 50090-3481; 0310-6205; 17228-6210; 12783-1427; 54921-620; 55154-6933; 46708-897; 66064-1029; 50193-1427; 59651-135; 0310-6210; 66039-933
Synonyms dapagliflozin | (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6- (hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | Farxiga | Forxiga | 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol | BMS 512148 | BMS512148 | BMS-512148
Chemical Information
Molecular Formula C21H25ClO6
CAS Registry Number 461432-26-8
SMILES CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vulvovaginal mycotic infection21.14.02.004; 11.03.05.0040.001206%Not Available
Soft tissue necrosis24.04.02.007; 15.03.02.0020.001206%
Type 1 diabetes mellitus10.04.08.007; 05.06.01.010; 14.06.01.0100.001809%Not Available
Oropharyngeal pain22.02.05.022; 07.05.05.0040.003618%
Acute kidney injury20.01.03.0160.012058%
Drug-induced liver injury12.03.01.044; 09.01.07.023--Not Available
Candida infection11.03.03.0210.004220%
Glomerular filtration rate abnormal13.13.01.0220.001809%Not Available
Overweight14.03.02.0210.001206%Not Available
Blood ketone body13.02.04.0080.001206%Not Available
Blood ketone body increased13.02.04.0090.001206%Not Available
Diabetic foot17.09.04.006; 14.07.06.001; 05.07.06.001; 24.04.03.015; 23.07.03.0080.001206%Not Available
Latent autoimmune diabetes in adults14.06.01.014; 10.04.08.011; 05.06.01.0140.001206%Not Available
Hyperosmolar hyperglycaemic state17.02.04.020; 14.07.04.006; 05.07.04.0060.001809%Not Available
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