Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dacarbazine
Drug ID BADD_D00568
Description An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Indications and Usage For the treatment of metastatic malignant melanoma. In addition, dacarbazine is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other antineoplastic agents.
Marketing Status Prescription; Discontinued
ATC Code L01AX04
DrugBank ID DB00851
KEGG ID D00288
MeSH ID D003606
PubChem ID 2942
TTD Drug ID D0Y7ZU
NDC Product Code 54875-0003; 0143-9245; 42973-149; 0703-5075; 63323-128; 63323-127
Synonyms Dacarbazine | Dimethyl Imidazole Carboxamide | Carboxamide, Dimethyl Imidazole | Imidazole Carboxamide, Dimethyl | DTIC | ICDT | Decarbazine | 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide | DIC | Dimethyl Triazeno Imidazole Carboxamide | NSC-45388 | NSC 45388 | NSC45388 | DTIC-Dome | DTIC Dome | DTICDome | Biocarbazine | Deticene
Chemical Information
Molecular Formula C6H10N6O
CAS Registry Number 4342-03-4
SMILES CN(C)N=NC1=C(NC=N1)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Paraesthesia17.02.06.005--
Photosensitivity reaction23.03.09.003--
Pneumonia22.07.01.003; 11.01.09.0030.000278%Not Available
Premature menopause21.02.02.004; 05.05.01.0160.000533%
Pyrexia08.05.02.0030.001332%
Rash23.03.13.0010.000533%Not Available
Rash erythematous23.03.06.003--Not Available
Rash maculo-papular23.03.13.0040.000533%
Seizure17.12.03.001--
Stomatitis07.05.06.005--
Tachycardia02.03.02.0070.001332%Not Available
Thrombocytopenia01.08.01.0020.000533%Not Available
Urticaria23.04.02.001; 10.01.06.001--
Venoocclusive liver disease24.04.07.002; 09.01.06.002--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.0030.001066%
Malignant neoplasm progression16.16.01.0050.000278%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Vascular occlusion24.04.02.015--Not Available
Hepatic vein occlusion24.04.07.005; 09.01.06.011--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Renal function test abnormal13.13.01.012--Not Available
Ill-defined disorder08.01.03.049--Not Available
Disease progression08.01.03.0380.000208%
Venoocclusive disease24.03.02.016--Not Available
Renal impairment20.01.03.0100.000533%Not Available
Bone marrow failure01.03.03.005--
Foetal growth restriction18.03.01.0020.000533%
Metastases to skin23.07.04.026; 16.22.02.0230.000533%Not Available
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