Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cytarabine hydrochloride
Drug ID BADD_D00561
Description A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Indications and Usage For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
Marketing Status Prescription; Discontinued
ATC Code L01BC01
DrugBank ID DB00987
KEGG ID D03637
MeSH ID D003561
PubChem ID 6252
TTD Drug ID D07XSN
NDC Product Code 12848-1003; 61703-303; 61703-319; 71288-108; 71288-168; 55512-0026; 67457-455; 68083-343; 71288-109; 61703-305; 71288-169; 58623-0026; 70516-0163; 61703-304; 63323-120; 67457-452; 68083-337
Synonyms Cytarabine | Arabinosylcytosine | Cytosine Arabinoside | Arabinoside, Cytosine | Arabinofuranosylcytosine | Aracytidine | beta-Ara C | beta Ara C | Cytarabine Hydrochloride | Cytosar | Cytosar-U | Cytosar U | Ara-C | Ara C | Aracytine | Cytonal
Chemical Information
Molecular Formula C9H13N3O5.ClH
CAS Registry Number 69-74-9
SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neurological symptom17.02.05.010--Not Available
Allergic oedema10.01.03.025; 08.01.07.014--Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Ocular toxicity12.03.01.031; 06.11.01.006--Not Available
Infestation11.09.01.001; 23.09.05.001--Not Available
Inflammation08.01.05.007--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Spinal cord disorder17.10.01.010--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Ill-defined disorder08.01.03.049--Not Available
Inner ear disorder04.04.02.002--Not Available
Polyp16.02.02.005; 08.01.06.010--Not Available
Sensation of foreign body08.01.09.002--Not Available
Blood disorder01.05.01.004--Not Available
Disease progression08.01.03.038--
Cranial nerve paralysis17.04.01.002--Not Available
Psychotic disorder19.03.01.002--
Pulmonary toxicity22.01.02.007; 12.03.01.013--Not Available
Hepatobiliary disease09.01.08.003--Not Available
Venoocclusive disease24.03.02.016--Not Available
Immunology test13.06.03.007--Not Available
Solar lentigo23.05.01.013--Not Available
Bone marrow failure01.03.03.005--
Liver injury09.01.07.022; 12.01.02.003--Not Available
Cytarabine syndrome15.03.04.016; 08.05.02.010--Not Available
Traumatic liver injury12.01.02.008; 09.01.08.010--Not Available
Oropharyngeal discomfort22.02.05.027; 07.05.05.008--Not Available
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