Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cyclizine
Drug ID BADD_D00543
Description A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
Indications and Usage For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo (dizziness caused by other medical problems).
Marketing Status Discontinued
ATC Code R06AE03
DrugBank ID DB01176
KEGG ID D03621
MeSH ID D003501
PubChem ID 6726
TTD Drug ID D08HRJ
NDC Product Code Not Available
Synonyms Cyclizine | Marezine | Cyclizine Hydrochloride | Hydrochloride, Cyclizine | Cyclizine HCl | HCl, Cyclizine
Chemical Information
Molecular Formula C18H22N2
CAS Registry Number 82-92-8
SMILES CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Altered state of consciousness19.07.01.003; 17.02.04.001--Not Available
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Apnoea22.02.01.001--
Asthenia08.01.01.001--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Chills15.05.03.016; 08.01.09.001--
Chorea17.01.01.001--Not Available
Constipation07.02.02.001--
Depressed level of consciousness17.02.04.002--
Dermatitis bullous23.03.01.002--
Discomfort08.01.08.003--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.015--Not Available
Dyskinesia17.01.02.006--
Erythema23.03.06.001--Not Available
Eye disorder06.08.03.001--Not Available
Fixed drug eruption23.03.05.006; 10.01.01.022; 08.01.06.017--Not Available
Hallucinations, mixed19.10.02.007--Not Available
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Hepatitis09.01.07.004--Not Available
Hepatitis cholestatic09.01.01.002--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypotension24.06.03.002--
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