Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cortisone
Drug ID BADD_D00532
Description A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite hydrocortisone. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
Indications and Usage For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
Marketing Status Not Available
ATC Code H02AB10; S01BA03
DrugBank ID DB14681
KEGG ID D07749
MeSH ID D003348
PubChem ID 222786
TTD Drug ID D0IX6I
NDC Product Code Not Available
Synonyms Cortisone | Cortisone Acetate | 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate | Cortone Acetate | Adreson
Chemical Information
Molecular Formula C21H28O5
CAS Registry Number 53-06-5
SMILES CC12CCC(=O)C=C1CCC3C2C(=O)CC4(C3CCC4(C(=O)CO)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Alanine aminotransferase increased13.03.01.003--
Alkalosis hypokalaemic14.01.02.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Benign intracranial hypertension17.07.02.001--Not Available
Carbohydrate tolerance decreased13.02.02.003--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cataract subcapsular06.06.01.002--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Discomfort08.01.08.003--Not Available
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Embolism venous24.01.01.003--Not Available
Erythema23.03.06.001--Not Available
Exophthalmos06.09.04.001; 05.02.02.002--Not Available
Feeling abnormal08.01.09.014--Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Glaucoma06.03.01.002--
Glucose tolerance impaired14.06.02.001; 05.06.02.001--
Haemoglobin13.01.05.018--Not Available
Headache17.14.01.001--
Hirsutism23.02.04.001; 05.05.01.005--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypernatraemia14.05.04.001--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Impaired healing08.03.02.001--Not Available
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Increased insulin requirement14.06.01.006; 05.06.01.006--Not Available
Inflammatory bowel disease07.08.01.016--Not Available
Injury12.01.08.004--Not Available
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