Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Corticotropin
Drug ID BADD_D00531
Description Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.
Indications and Usage Hellman P, Linder F, Hennings J, Hessman O, Eriksson B, Orlefors H, Akerstrom G: Bilateral adrenalectomy for ectopic Cushing's syndrome-discussions on technique and indication. World J Surg. 2006 May;30(5):909-16.
Marketing Status Prescription; Discontinued
ATC Code H01AA01
DrugBank ID DB01285
KEGG ID D00146
MeSH ID D000324
PubChem ID 16132265
TTD Drug ID D0R4HQ
NDC Product Code 61200-004; 38779-1904; 59149-005; 63474-200
Synonyms Adrenocorticotropic Hormone | Hormone, Adrenocorticotropic | ACTH (1-39) | ACTH | Corticotrophin | Corticotropin | Corticotropin (1-39) | Corticotrophin (1-39) | Adrenocorticotrophic Hormone | Hormone, Adrenocorticotrophic | 1-39 ACTH | Adrenocorticotropin
Chemical Information
Molecular Formula C207H308N56O58S
CAS Registry Number 9002-60-2
SMILES CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C2CCCN2C(=O)C(CC3=CC= CC=C3)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCC(=O)O)NC(=O)C(C C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CC(=O)N)NC(=O)C4CCCN4C(=O)C(CC5 =CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCCN)NC(=O)C(C(C)C)NC(=O)C6CCCN6C(=O)C(CCCNC (=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(C(C)C)NC(=O) C7CCCN7C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC8=CNC9=CC=CC=C98)NC(=O)C(CCCNC(=N)N)NC(=O)C (CC1=CC=CC=C1)NC(=O)C(CC1=CN=CN1)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O) C(CC1=CC=C(C=C1)O)NC(=O)C(CO)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Food malabsorption and intolerance syndromes (excl sugar intolerance)Urotensin-2Q9QZQ4Not Available26297349
Food malabsorption and intolerance syndromes (excl sugar intolerance)Agouti related protein homolog (Mouse)F1MAG1Not Available26297349
Food malabsorption and intolerance syndromes (excl sugar intolerance)Agouti related proteinQ9QXJ3Not Available26297349
Food malabsorption and intolerance syndromes (excl sugar intolerance)Melanocyte-stimulating hormone receptorB6ZGR5Not Available26297349
Food malabsorption and intolerance syndromes (excl sugar intolerance)CorticoliberinP01143Not Available26297349
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abscess11.01.08.001--Not Available
Acne23.02.01.001--Not Available
Alkalosis hypokalaemic14.01.02.002--Not Available
Benign intracranial hypertension17.07.02.001--Not Available
Body temperature increased13.15.01.001--Not Available
Brain compression17.07.02.005--Not Available
Carbohydrate tolerance decreased13.02.02.003--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiac hypertrophy02.04.02.017--Not Available
Constipation07.02.02.001--
Cushingoid19.07.03.001; 14.11.01.006; 05.01.01.002; 24.08.02.004--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Ecchymosis23.06.01.001; 01.01.03.001; 24.07.06.002--Not Available
Endocrine disorder05.09.01.001--Not Available
Erythema23.03.06.001--Not Available
Exophthalmos06.09.04.001; 05.02.02.002--Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.008--
Headache17.14.01.001--
Hirsutism23.02.04.001; 05.05.01.005--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Impaired healing08.03.02.001--Not Available
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Infection11.01.08.002--Not Available
The 1th Page    1 2 3    Next   Last    Total 3 Pages