Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Colchicine
Drug ID BADD_D00518
Description First approved by the FDA in 1961, colchicine is an alkaloid drug commonly used in the management of gout, a condition associated with the painful deposition of urate crystals in the joints.[A183614,L8138] It is derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus".[A183611] Other than its use in gout, colchicine has been approved for managing exacerbations of Familial Mediterranean Fever (FMF), a hereditary autoinflammatory condition.[A186320,L8141]
Indications and Usage For treatment and relief of pain in attacks of acute gouty arthritis.
Marketing Status Prescription
ATC Code M04AC01
DrugBank ID DB01394
KEGG ID D00570
MeSH ID D003078
PubChem ID 6167
TTD Drug ID D09DHY
NDC Product Code 75854-801; 0378-1086; 0591-2562; 68071-2567; 55742-127; 49452-2210; 43353-854; 43598-372; 63629-2167; 63629-8362; 70710-1351; 50268-187; 66064-1008; 59651-455; 59467-318; 64764-119; 31722-899; 63187-292; 65162-710; 72189-331; 72189-249; 63629-7422; 47234-0119; 0254-2008; 17359-5000; 0143-3018; 0904-7120; 16714-039; 63629-2166; 63629-8766; 70771-1590; 0904-6732; 61281-3600; 69037-0011; 71205-310; 71335-1802; 71610-494; 51927-1895; 68404-0001; 67296-1708; 60687-358; 72643-009; 70771-1396; 67877-589; 51407-082; 42292-054; 70010-002; 71335-1695; 70710-1571; 71335-1738; 60687-389
Synonyms Colchicine | Colchicine, (R)-Isomer | Colchicine, (+-)-Isomer
Chemical Information
Molecular Formula C22H25NO6
CAS Registry Number 64-86-8
SMILES CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oliguria20.01.03.004--Not Available
Pain in extremity15.03.04.0100.000571%
Pancytopenia01.03.03.0030.001143%Not Available
Peripheral motor neuropathy17.09.03.004--
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Rash23.03.13.001--Not Available
Rash maculo-papular23.03.13.004--
Rhabdomyolysis15.05.05.002--
Shock24.06.02.002--Not Available
Sinusitis22.07.03.007; 11.01.13.0050.000571%
Skin disorder23.03.03.007--Not Available
Somnolence19.02.05.003; 17.02.04.0060.000571%
Steatorrhoea07.17.01.002--Not Available
Stomatitis07.05.06.005--
Thrombocytopenia01.08.01.002--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vascular purpura24.07.06.011; 23.06.01.008; 01.01.04.007--Not Available
Vomiting07.01.07.003--
Bladder spasm20.02.02.013--
Central nervous system lesion17.02.10.011--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Purpura non-thrombocytopenic01.01.04.006--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Myotonia17.05.02.013; 15.05.04.013--Not Available
Blood disorder01.05.01.004--Not Available
Drug intolerance08.06.01.0130.000571%Not Available
Ulcerative keratitis10.02.01.021; 06.04.02.004--
Bone marrow failure01.03.03.005--
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