Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Colchicine
Drug ID BADD_D00518
Description First approved by the FDA in 1961, colchicine is an alkaloid drug commonly used in the management of gout, a condition associated with the painful deposition of urate crystals in the joints.[A183614,L8138] It is derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus".[A183611] Other than its use in gout, colchicine has been approved for managing exacerbations of Familial Mediterranean Fever (FMF), a hereditary autoinflammatory condition.[A186320,L8141]
Indications and Usage For treatment and relief of pain in attacks of acute gouty arthritis.
Marketing Status Prescription
ATC Code M04AC01
DrugBank ID DB01394
KEGG ID D00570
MeSH ID D003078
PubChem ID 6167
TTD Drug ID D09DHY
NDC Product Code 75854-801; 0378-1086; 0591-2562; 68071-2567; 55742-127; 49452-2210; 43353-854; 43598-372; 63629-2167; 63629-8362; 70710-1351; 50268-187; 66064-1008; 59651-455; 59467-318; 64764-119; 31722-899; 63187-292; 65162-710; 72189-331; 72189-249; 63629-7422; 47234-0119; 0254-2008; 17359-5000; 0143-3018; 0904-7120; 16714-039; 63629-2166; 63629-8766; 70771-1590; 0904-6732; 61281-3600; 69037-0011; 71205-310; 71335-1802; 71610-494; 51927-1895; 68404-0001; 67296-1708; 60687-358; 72643-009; 70771-1396; 67877-589; 51407-082; 42292-054; 70010-002; 71335-1695; 70710-1571; 71335-1738; 60687-389
Synonyms Colchicine | Colchicine, (R)-Isomer | Colchicine, (+-)-Isomer
Chemical Information
Molecular Formula C22H25NO6
CAS Registry Number 64-86-8
SMILES CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal pain07.01.05.005--
Gout15.01.06.001; 14.09.01.0010.002000%Not Available
Granulocytopenia01.02.03.003--Not Available
Haematochezia24.07.02.012; 07.12.02.0030.000571%Not Available
Haematuria24.07.01.047; 20.02.01.006--
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Hepatocellular injury09.01.07.008--Not Available
Hypersensitivity10.01.03.003--
Hypoaesthesia17.02.06.023--Not Available
Hypotension24.06.03.002--
Hypothyroidism14.11.01.012; 05.02.03.001--
Ileus paralytic07.02.05.001--Not Available
Judgement impaired19.05.01.009; 17.03.03.0050.000571%Not Available
Lactase deficiency14.02.02.003; 07.17.01.006--Not Available
Lactose intolerance14.02.02.001; 07.17.01.003--Not Available
Laryngeal pain22.02.05.036--
Leukopenia01.02.02.001--Not Available
Malabsorption14.02.01.004; 07.17.01.001--
Metabolic acidosis14.01.01.003--Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.0010.000571%
Myopathy15.05.05.001--Not Available
Nausea07.01.07.0010.001714%
Nervous system disorder17.02.10.001--Not Available
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Oligospermia21.03.03.005--
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