Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Codeine
Drug ID BADD_D00516
Description The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain without impairing consciousness or altering other sensory functions. Opiates such as codeine are derived from the poppy plant, _Papaver somniferum_ (Papaveraceae).[A175096] Codeine is utilized as a central analgesic, sedative, hypnotic, antinociceptive, and antiperistaltic agent, and is also recommended in certain diseases with incessant coughing.[LABEL,A175096]
Indications and Usage For treatment and management of pain (systemic). It is also used as an antidiarrheal and as a cough suppressant.
Marketing Status Not Available
ATC Code R05DA04
DrugBank ID DB00318
KEGG ID C06174
MeSH ID D003061
PubChem ID 5284371
TTD Drug ID D03DIG
NDC Product Code Not Available
Synonyms Codeine | Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)- | N-Methylmorphine | N Methylmorphine | Isocodeine | Codeine Phosphate | Ardinex
Chemical Information
Molecular Formula C18H21NO3
CAS Registry Number 76-57-3
SMILES CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(C=C4)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Depressed level of consciousnessCytochrome P450 2D6P10635T5739210772431; 15748098; 10983742
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dry mouth07.06.01.002--
Dysphoria19.04.02.004--Not Available
Dyspnoea22.02.01.004; 02.01.03.002--
Erythema23.03.06.001--Not Available
Euphoric mood19.04.02.006--
Eye disorder06.08.03.001--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Formication19.10.02.010; 17.02.06.0180.001531%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Hallucination19.10.02.0020.001531%
Hyperhidrosis23.02.03.004; 08.01.03.0280.001531%
Hypersensitivity10.01.03.0030.003828%
Hypotension24.06.03.002--
Hypothermia12.05.03.001; 08.05.01.003--
Immune system disorder10.02.01.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Intracranial pressure increased17.07.02.002--Not Available
Irritability19.04.02.013; 08.01.03.011--
Lacrimation increased06.08.02.004--
Loss of consciousness17.02.04.004--Not Available
Loss of libido19.08.03.003--Not Available
Malaise08.01.01.003--
Miosis06.05.03.003; 17.02.11.002--Not Available
Mood swings19.04.03.001--Not Available
Muscle rigidity17.05.02.005; 15.05.04.001--Not Available
Muscle spasms15.05.03.004--
Mydriasis06.05.03.004; 17.02.11.003--Not Available
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