Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status approved
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII J60AR2IKIC
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eating disorder19.09.01.008; 14.03.01.0080.026169%Not Available
Eczema23.03.04.006--
Ejaculation disorder21.03.01.002--
Electrocardiogram QT prolonged13.14.05.004--
Electroencephalogram abnormal13.07.03.001--Not Available
Electrolyte imbalance14.05.01.002--Not Available
Embolism venous24.01.01.003--Not Available
Emphysema22.01.02.0020.009171%Not Available
Encephalopathy17.13.02.001--
Endometrial cancer21.07.02.002; 16.12.02.0010.004891%Not Available
Enuresis20.02.02.003; 19.07.04.0010.022990%Not Available
Enzyme abnormality14.11.01.015--Not Available
Eosinopenia01.02.02.0030.003913%Not Available
Eosinophilia01.02.04.0010.125221%
Eosinophilic myocarditis02.04.03.002; 01.02.04.0070.003057%Not Available
Eosinophilic pneumonia22.01.01.004; 01.02.04.0030.006726%Not Available
Epilepsy17.12.03.002--Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Eructation07.01.02.003--
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Extrapyramidal disorder17.01.02.007--
Eye disorder06.08.03.001--Not Available
Faeces hard07.01.03.0030.001834%Not Available
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.0080.007949%Not Available
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.002--
Feeling abnormal08.01.09.014--Not Available
Fibroma16.02.02.010; 15.09.01.0040.004280%Not Available
Flat affect19.04.01.0040.002446%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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