Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clopidogrel
Drug ID BADD_D00504
Description Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.[A180547] Clopidogrel was granted FDA approval on 17 November 1997.[L7213]
Indications and Usage For the reduction of atherosclerotic events (myocardial infarction, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.
Marketing Status Prescription; Discontinued
ATC Code B01AC04
DrugBank ID DB00758
KEGG ID D07729
MeSH ID D000077144
PubChem ID 60606
TTD Drug ID D0N0TZ
NDC Product Code 65977-0037; 0093-7314; 16729-218; 42543-713; 71335-1409; 42543-714; 65162-414; 68788-7645; 52605-083; 50090-5781; 50090-4918; 70518-0400; 61919-737; 52605-082; 63653-1171; 0024-1332; 63187-362; 70934-708; 61919-007; 33342-060; 68071-1578; 70771-1062; 68071-4138; 71335-0581; 63629-4728; 16729-219; 63653-1332; 0024-1171; 72578-012
Synonyms Clopidogrel | SC 25989C | SC 25990C | SR 25989 | Clopidogrel-Mepha | Clopidogrel Mepha | Clopidogrel Sandoz | Iscover | Clopidogrel Napadisilate | Clopidogrel Hydrochloride | PCR 4099 | PCR-4099 | Clopidogrel Besylate | Clopidogrel Besilate | Clopidogrel, (+)(S)-isomer | Plavix | Clopidogrel Bisulfate
Chemical Information
Molecular Formula C16H16ClNO2S
CAS Registry Number 113665-84-2
SMILES COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactoid reaction24.06.03.007; 10.01.07.0030.000098%Not Available
Aneurysm24.02.01.0010.000026%Not Available
Angina pectoris24.04.04.002; 02.02.02.0020.001815%
Angina unstable24.04.04.004; 02.02.02.0040.000589%Not Available
Angioedema23.04.01.001; 10.01.05.0090.001717%Not Available
Anhedonia19.15.02.007--Not Available
Anisocytosis01.07.02.0080.000098%Not Available
Anuria20.01.03.0020.000196%Not Available
Anxiety19.06.02.002--
Aortic aneurysm24.02.03.0010.000038%Not Available
Aortic aneurysm rupture24.02.03.0030.000026%Not Available
Aortic dissection24.02.03.0020.000038%Not Available
Aortic stenosis24.04.01.0010.000147%Not Available
Aortic thrombosis24.01.09.0010.000245%Not Available
Aortic valve incompetence02.07.03.0010.000147%Not Available
Aortic valve stenosis02.07.03.0040.000098%Not Available
Apathy19.04.04.002--Not Available
Aphasia19.21.01.001; 17.02.03.0010.002404%
Aplastic anaemia01.03.03.002--Not Available
Apnoea22.02.01.001--
Areflexia17.02.01.0010.000147%Not Available
Arrhythmia02.03.02.001--Not Available
Arrhythmia supraventricular02.03.03.0010.000098%Not Available
Arterial injury24.11.02.002; 12.01.11.0080.000147%
Arterial thrombosis24.01.01.0020.000098%Not Available
Arteriosclerosis24.04.02.0010.000102%Not Available
Arteriosclerosis coronary artery24.04.04.012; 02.02.01.0110.000038%Not Available
Arteriospasm coronary24.04.04.005; 02.02.02.0050.000147%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
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