Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clobazam
Drug ID BADD_D00488
Description Clobazam belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. The oral preparation was FDA approved on October 21, 2011. An oral suspension is expected to be available in 2013.
Indications and Usage For treatment and management of epilepsy and seizures associated with Lennox-Gastaut syndrome, a difficult-to-treat form of childhood epilepsy.
Marketing Status approved; illicit
ATC Code N05BA09
DrugBank ID DB00349
KEGG ID D01253
MeSH ID D000078306
PubChem ID 2789
TTD Drug ID D0S9MC
NDC Product Code 0781-8014; 82348-103; 69238-1305; 72205-047; 72606-003; 0832-0580; 10094-205; 10094-220; 69037-0009; 16729-446; 67877-658; 68180-156; 68180-158; 70710-1325; 70771-1441; 72205-048; 72606-004; 11014-0114; 42571-308; 48087-0117; 16714-888; 62135-527; 67386-315; 67877-665; 69452-116; 67877-666; 0832-0581; 51991-900; 59651-401; 69452-115; 10094-210; 31722-640; 42571-315; 51672-4202; 60687-423; 67386-314; 69238-1535; 69539-154; 65085-0054; 16714-887; 31722-639; 51672-4227; 66689-058; 11014-0115; 68180-157; 69238-1306; 69452-114; 70710-1326; 47621-047; 16729-445; 31722-641; 51672-4203; 0781-8013; 12828-0084; 69766-016; 16714-087; 51672-4210; 67386-313; 69539-153; 70771-1440; 48087-0094; 64330-110; 42571-316; 51991-901; 51991-958
UNII 2MRO291B4U
Synonyms Clobazam | Urbanyl | Onfi | 1-Phenyl-5-methyl-8-chloro-1,2,4,5- tetrahydro-2,4-diketo-3H-1,5-benzodiazepine | HR 376 | LM-2717 | LM 2717 | LM2717 | Frisium
Chemical Information
Molecular Formula C16H13ClN2O2
CAS Registry Number 22316-47-8
SMILES CN1C(=O)CC(=O)N(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eosinophilia01.02.04.001--
Epilepsy17.12.03.0020.000745%Not Available
Erythema multiforme10.01.03.015; 23.03.01.003--
Euphoric mood19.04.02.006--
Eye disorder06.08.03.001--Not Available
Fatigue08.01.01.0020.007814%
Feeling abnormal08.01.09.014--Not Available
Flat affect19.04.01.004--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Generalised tonic-clonic seizure17.12.01.0020.000196%Not Available
Hallucination19.10.04.003--
Hallucination, auditory19.10.04.0040.000287%Not Available
Hangover08.01.09.018--Not Available
Headache17.14.01.001--
Hepatic failure09.01.03.0020.000131%
Hepatocellular injury09.01.07.0080.000131%Not Available
Hostility19.05.01.003--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyponatraemia14.05.04.0020.000457%
Hypotension24.06.03.002--
Hypothermia12.05.03.001; 08.05.01.0030.000588%
Ileus07.13.01.0010.000131%
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Infection11.01.08.002--Not Available
Initial insomnia19.02.01.005; 17.15.03.0050.000510%Not Available
Insomnia19.02.01.002; 17.15.03.0020.002639%
Irritability19.04.02.013; 08.01.03.0110.002130%
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.000549%
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
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ADReCS-Target
Drug Name ADR Term Target
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