Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cladribine
Drug ID BADD_D00479
Description An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
Indications and Usage For the treatment of active hairy cell leukemia (leukemic reticuloendotheliosis) as defined by clinically significant anemia, neutropenia, thrombocytopenia, or disease-related symptoms. Also used as an alternative agent for the treatment of chronic lymphocytic leukemia (CLL), low-grade non-Hodgkin's lymphoma, and cutaneous T-cell lymphoma.
Marketing Status Prescription; Discontinued
ATC Code L01BB04; L04AA40
DrugBank ID DB00242
KEGG ID D01370
MeSH ID D017338
PubChem ID 20279
TTD Drug ID D05GJW
NDC Product Code 65129-1260; 67457-450; 63323-140; 42658-010; 54893-0115; 59605-3006; 58623-0037; 12502-4912; 0143-9871; 12502-5406; 44087-4000
Synonyms Cladribine | 2-Chlorodeoxyadenosine | 2-Chloro-2'-deoxyadenosine | 2'-Deoxy-2-chloroadenosine | Leustatin
Chemical Information
Molecular Formula C10H12ClN5O3
CAS Registry Number 4291-63-8
SMILES C1C(C(OC1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ureteric obstruction20.06.01.005--Not Available
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
Urinary tract infection20.08.02.001; 11.01.14.0040.001095%
Urticaria23.04.02.001; 10.01.06.0010.001825%
Vascular purpura23.06.01.008; 24.07.06.011; 01.01.04.007--Not Available
Vertigo17.02.12.002; 04.04.01.0030.001095%
Viral infection11.05.04.001--Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Wheezing22.03.01.009--
White blood cell count decreased13.01.06.0120.002919%
Wound infection12.01.08.012; 11.01.08.0100.000730%
Mobility decreased17.02.05.018; 15.03.01.003; 08.01.03.0300.000730%Not Available
Multiple sclerosis relapse17.16.01.0030.013867%Not Available
Urosepsis20.08.02.002; 11.01.11.0050.000730%Not Available
Localised oedema14.05.06.009; 08.01.07.011; 02.05.04.006--
Quadriparesis17.01.04.012--Not Available
Contusion24.07.06.001; 23.03.11.002; 15.03.01.008; 12.01.06.001--
Systemic inflammatory response syndrome08.01.05.005; 24.06.03.008; 10.02.01.0080.000730%Not Available
Malignant neoplasm progression16.16.01.0050.000190%Not Available
Lymphatic disorder01.09.01.003--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Catheter site cellulitis11.02.01.030; 08.02.02.011; 23.09.01.017; 12.07.02.011--Not Available
Type IV hypersensitivity reaction10.01.03.0220.001460%Not Available
Transaminases increased13.03.01.015--Not Available
Infusion site reaction12.07.05.006; 08.02.05.005--Not Available
Haemorrhage24.07.01.002--Not Available
Enteritis infectious11.01.07.016; 07.19.01.009--
Angiopathy24.03.02.007--Not Available
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