Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cinacalcet hydrochloride
Drug ID BADD_D00469
Description Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Indications and Usage For the treatment of secondary hyperparathyroidism in patients with Chronic Kidney Disease who are on hemodialysis or peritoneal dialysis. Also for the treatment of hypercalcemia in patients with parathyroid carcinoma.
Marketing Status Prescription
ATC Code H05BX01
DrugBank ID DB01012
KEGG ID D03505
MeSH ID D000069449
PubChem ID 156418
TTD Drug ID D03YGR
NDC Product Code 65977-0110; 50379-0016; 50090-3529; 49706-2030; 65862-799; 65096-0114; 63415-0528; 71093-152; 71093-153; 53747-056; 55513-073; 70436-007; 50090-4470; 65372-1165; 55111-959; 68259-1302; 55513-075; 53104-7699; 65085-0052; 58159-055; 55513-074; 70436-008; 71093-154; 63126-910; 70436-009; 16436-0082
Synonyms Cinacalcet | Cinacalcet Hydrochloride | Alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-naphthalenemethanamine, (alphaR)-hydrochloride | Sensipar | AMG 073 | KRN 1493 | AMG073
Chemical Information
Molecular Formula C22H23ClF3N
CAS Registry Number 364782-34-3
SMILES CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Anaemia01.03.02.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.004--Not Available
Cardiac failure02.05.01.001--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Constipation07.02.02.001--
Cough22.02.03.001--
Dehydration14.05.05.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspepsia07.01.02.001--
Dyspnoea02.01.03.002; 22.02.01.004--
Fatigue08.01.01.002--
Fracture15.08.02.001; 12.04.02.001--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009--Not Available
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Hypercalcaemia14.04.01.003; 05.04.01.002--
Hyperparathyroidism primary05.04.01.005--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypocalcaemia14.04.01.004--
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