Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cidofovir dihydrate
Drug ID BADD_D00464
Description Cidofovir is an injectable antiviral medication employed in the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS. It suppresses CMV replication through selective inhibition of viral DNA synthesis.[FDA label] It was manufactured by _Gilead_ and initially approved by the FDA in 1996, but has since been discontinued.[L6223]
Indications and Usage For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)
Marketing Status Prescription; Discontinued
ATC Code J05AB12
DrugBank ID DB00369
KEGG ID D00273
MeSH ID D000077404
PubChem ID 60933
TTD Drug ID D04AAW
NDC Product Code 23155-216; 43744-064; 73377-064; 73309-228; 71052-483; 14593-840
Synonyms Cidofovir | HPMPC | GS 504 | GS-504 | GS504 | Cidofovir, Sodium Salt | Cidofovir Sodium | Cidofovir, (R)-isomer | Cidofovir Anhydrous | 1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine | 1-((3-Hydroxy-2-phosphonylmethoxy)propyl)cytosine | Vistide | Cidofovir, (+-)-isomer
Chemical Information
Molecular Formula C8H18N3O8P
CAS Registry Number 149394-66-1
SMILES C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O.O.O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ApoptosisCaspase-3P42574T57943Not Available
ApoptosisPre-mRNA-processing factor 19Q9UMS4Not AvailableNot Available
ApoptosisCellular tumor antigen p53P04637T15739Not Available
ApoptosisPutative cyclin-dependent kinase inhibitor 1A (P21/WAF1/CIP1)Q683K8Not AvailableNot Available
Nephropathy toxicSolute carrier family 22 member 6Q4U2R8Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hemiplegia17.01.04.002--Not Available
Hepatic function abnormal09.01.02.001--Not Available
Hepatic necrosis09.01.07.002--
Hepatitis09.01.07.004--Not Available
Hepatomegaly09.01.05.001--Not Available
Hepatosplenomegaly09.01.05.002; 01.09.03.001--Not Available
Herpes simplex11.05.02.001; 23.09.03.001--Not Available
Hiccups22.02.04.002; 07.01.06.009--
Hyperacusis17.04.03.003; 04.02.02.001--Not Available
Hyperaesthesia17.02.06.004--Not Available
Hypercalcaemia14.04.01.003; 05.04.01.002--
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkalaemia14.05.03.001--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hyperventilation19.01.02.004; 22.02.01.006--Not Available
Hypocalcaemia14.04.01.004--
Hypochromic anaemia01.03.02.004--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypokalaemia14.05.03.002--
Hypomagnesaemia14.04.02.001--
Hyponatraemia14.05.04.002--
Hypophosphataemia14.04.03.001--
Hypoproteinaemia14.10.01.003; 09.01.02.004--Not Available
Hypotension24.06.03.002--
Hypothermia12.05.03.001; 08.05.01.003--
Hypotonia17.05.02.002; 15.05.04.008--Not Available
Hypotony of eye06.08.03.004--Not Available
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