Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Chloramphenicol
Drug ID BADD_D00430
Description An antibiotic first isolated from cultures of _Streptomyces venequelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
Indications and Usage Used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.
Marketing Status Discontinued
ATC Code D06AX02; D10AF03; G01AA05; J01BA01; S01AA01; S02AA01; S03AA08
DrugBank ID DB00446
KEGG ID D00104
MeSH ID D002701
PubChem ID 5959
TTD Drug ID D0X6IU
NDC Product Code 59929-783; 62991-1031; 53069-0010; 38779-0203; 51927-0214; 71052-687; 72969-011; 66478-0155; 64677-0002; 79572-005
Synonyms Chloramphenicol | Kloramfenikol | Cloranfenicol | Chlornitromycin | Chlorocid | Amphenicol | Amphenicols | Ophthochlor | Syntomycin | Levomycetin | Chloromycetin | Detreomycin
Chemical Information
Molecular Formula C11H12Cl2N2O5
CAS Registry Number 56-75-7
SMILES C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Jarisch-Herxheimer reaction10.02.01.002--Not Available
Leukaemia16.01.03.001; 01.10.03.001--
Leukopenia01.02.02.001--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Ocular hyperaemia06.04.05.004--Not Available
Pain08.01.08.004--
Pancytopenia01.03.03.003--Not Available
Paroxysmal nocturnal haemoglobinuria24.01.01.015; 20.02.01.022; 01.06.03.003--Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Rash maculo-papular23.03.13.004--
Rash vesicular23.03.13.009--Not Available
Respiratory disorder22.02.07.002--Not Available
Shock24.06.02.002--Not Available
Skin disorder23.03.03.007--Not Available
Stomatitis07.05.06.005--
Thrombocytopenia01.08.01.002--Not Available
Typhoid fever07.19.02.014; 11.02.19.004--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
Conjunctival hyperaemia06.04.01.004--Not Available
Lymphatic disorder01.09.01.003--Not Available
Blood disorder01.05.01.004--Not Available
Reaction to drug excipients10.01.01.023--Not Available
Bone marrow failure01.03.03.005--
Irregular breathing22.02.01.026--Not Available
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