Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cevimeline hydrochloride
Drug ID BADD_D00425
Description Cevimeline is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögren's syndrome.
Indications and Usage For the treatment of symptoms of dry mouth in patients with Sjögren's Syndrome.
Marketing Status Prescription; Discontinued
ATC Code N07AX03
DrugBank ID DB00185
KEGG ID D00661
MeSH ID C059240
PubChem ID 123603
TTD Drug ID D0Q4CS
NDC Product Code 0054-0334; 46014-1002; 63395-201; 42973-228; 72166-012; 16571-657; 58159-087; 40032-999; 66406-0269; 43386-999
Synonyms cevimeline | 2-methyspiro(1,3-oxathiolane-5,3)quinuclidine | AF 102B, (trans)-isomer | AF-102B | AF 102B | AF102B | Evoxac | FKS 508 | FKS-508 | SNI 2011 | SNI-2011 | AF 102B, (cis-(+))-isomer | cevimeline hydrochloride
Chemical Information
Molecular Formula C10H18ClNOS
CAS Registry Number 107220-28-0
SMILES CC1OC2(CN3CCC2CC3)CS1.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Back pain15.03.04.005--
Basal cell carcinoma23.08.02.001; 16.03.02.001--Not Available
Basosquamous carcinoma16.16.01.012--Not Available
Bladder discomfort20.02.02.019--Not Available
Blepharitis23.03.04.012; 06.04.04.001--Not Available
Blood creatine phosphokinase increased13.04.01.001--
Blood lactate dehydrogenase increased13.04.02.002--
Blood pressure fluctuation24.06.01.002--Not Available
Blood urea increased13.13.01.006--Not Available
Bone disorder15.02.04.004--Not Available
Bone pain15.02.01.001--
Breast cancer21.05.01.003; 16.10.01.001--Not Available
Breast neoplasm21.05.01.004; 16.10.02.001--Not Available
Breast pain21.05.05.003--
Bronchitis11.01.09.001; 22.07.01.001--
Bronchospasm22.03.01.004; 10.01.03.012--
Bundle branch block02.03.01.009--Not Available
Bursitis15.04.01.001--Not Available
Cardiac murmur13.14.01.001--Not Available
Cardiomegaly02.04.02.001--Not Available
Carpal tunnel syndrome17.09.02.001--Not Available
Cataract06.06.01.001--
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Change of bowel habit07.02.03.002--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Choking22.02.05.001--Not Available
Cholecystitis09.03.01.001--
Cholelithiasis09.03.01.002--Not Available
Cholinergic syndrome17.05.01.002--Not Available
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