Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ceftriaxone sodium
Drug ID BADD_D00406
Description Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic.[A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges[A215582], eyes[A215647], and inner ear[A215627]. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. Ceftriaxone is a commonly used antimicrobial due to its good activity against multi-drug resistant Enterobacteriaceae, its relatively safe adverse effect profile, and its long half-life which allows for the convenience of daily or twice-daily dosing.[A215582]
Indications and Usage For the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Marketing Status Prescription; Discontinued
ATC Code J01DD04
DrugBank ID DB01212
KEGG ID D00924
MeSH ID D002443
PubChem ID 9570985
TTD Drug ID D07ACT
NDC Product Code 50090-2444; 60505-6151; 50090-0944; 0409-7338; 0409-7335; 50090-3810; 67184-1007; 67184-1006; 50090-4978; 25021-108; 70518-3099; 50090-3838; 38779-2383; 0409-7332; 0781-3209; 71205-545; 67184-1008; 0409-7334; 60505-6152; 70518-2499; 70518-0168; 68071-4682; 50090-3447; 0781-3210; 67184-1005; 0781-3206; 0338-5003; 0781-3207; 0338-5002; 70518-2301; 50090-1875; 0409-7333; 60505-6149; 0781-3208; 0409-7337; 51065-004; 50090-4689; 0409-7336; 60505-6150; 60505-6148; 66288-6100
Synonyms Ceftriaxone | Ceftriaxon | Cefatriaxone | Ceftriaxone, Disodium Salt, Hemiheptahydrate | Ceftrex | Ceftriaxon Curamed | Ceftriaxon Hexal | Ceftriaxona Andreu | Ceftriaxona LDP Torlan | Ceftriaxone Irex | Ceftriaxone Sodium | Ceftriaxone Sodium, Anhydrous | Anhydrous Ceftriaxone Sodium | Lendacin | Longacef | Longaceph | Ro13-9904 | Ro13 9904 | Ro139904 | Ro-13-9904 | Ro 13-9904 | Ro 13 9904 | Ro 139904 | Rocephin | Rocefalin | Rocephine | Rocefin | Tacex | Terbac | Ceftriaxone, Disodium Salt | Benaxona | Cefaxona
Chemical Information
Molecular Formula C18H16N8Na2O7S3
CAS Registry Number 73384-59-5
SMILES CN1C(=NC(=O)C(=N1)[O-])SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-] .[Na+].[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Prothrombin time shortened13.01.02.013--Not Available
Pruritus23.03.12.001--
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Psychomotor hyperactivity19.11.02.003; 17.01.02.011--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Renal disorder20.01.02.002--Not Available
Seizure17.12.03.001--
Serum sickness12.02.08.004; 10.01.03.004--
Serum sickness-like reaction10.01.03.005; 08.01.03.003--Not Available
Skin reaction23.03.03.013; 10.01.03.019--Not Available
Stomatitis07.05.06.005--
Superinfection11.01.08.009--Not Available
Tenderness08.01.08.005--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombocytosis01.08.02.001--Not Available
Ureteric obstruction20.06.01.005--Not Available
Urine glucose false positive13.02.02.006--Not Available
Urticaria10.01.06.001; 23.04.02.001--
Vaginal infection21.14.02.002; 11.01.10.002--
Vomiting07.01.07.003--
Acute generalised exanthematous pustulosis23.03.10.002; 12.03.01.005--Not Available
Muscle tightness15.05.03.007--Not Available
Haemorrhage24.07.01.002--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Induration08.01.03.020--Not Available
Genital infection fungal21.10.03.003; 11.03.05.003--Not Available
Renal impairment20.01.03.010--Not Available
Acute kidney injury20.01.03.016--
Candida infection11.03.03.021--
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