Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ceftobiprole
Drug ID BADD_D00404
Description Ceftobiprole is a cephalosporin antibiotic with activity against methicillin-resistant Staphylococcus aureus. It was discovered by Basilea Pharmaceutica and is being developed by Johnson & Johnson Pharmaceutical Research and Development. Ceftobiprole is the first cephalosporin to demonstrate clinical efficacy in patients with infections due to methicillin-resistant staphylococci and, if approved by regulatory authorities, is expected to be a useful addition to the armamentarium of agents for the treatment of complicated skin infections and pneumonia.
Indications and Usage For the treatment of serious bacterial infections in hospitalised patients.
Marketing Status Not Available
ATC Code Not Available
DrugBank ID DB04918
KEGG ID D08885
MeSH ID C443755
PubChem ID 135413542
TTD Drug ID D0CI9T
NDC Product Code Not Available
Synonyms ceftobiprole | BAL9141 | BAL 9141
Chemical Information
Molecular Formula C20H22N8O6S2
CAS Registry Number 209467-52-7
SMILES C1CNCC1N2CCC(=CC3=C(N4C(C(C4=O)NC(=O)C(=NO)C5=NSC(=N5)N)SC3)C(=O)O)C2=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Fungal infection11.03.05.001--Not Available
Gamma-glutamyltransferase increased13.03.01.011--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hyponatraemia14.05.04.002--
Immune system disorder10.02.01.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Liver function test abnormal13.03.01.013--Not Available
Menopausal symptoms21.02.02.002--Not Available
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Oedema peripheral14.05.06.011; 02.05.04.007; 08.01.07.007--
Osteomyelitis15.02.05.001; 11.01.01.001--
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Phlebitis24.05.03.001; 12.02.01.002--
Pollakiuria20.02.02.007--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Rash maculo-papular23.03.13.004--
Seizure17.12.03.001--
Skin disorder23.03.03.007--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Thrombocytosis01.08.02.001--Not Available
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