Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cefotaxime
Drug ID BADD_D00390
Description Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).
Indications and Usage Used to treat gonorrhoea, meningitis, and severe infections including infections of the kidney (pyelonephritis) and urinary system. Also used before an operation to prevent infection after surgery.
Marketing Status Prescription; Discontinued
ATC Code J01DD01
DrugBank ID DB00493
KEGG ID D07647
MeSH ID D002439
PubChem ID 5742673
TTD Drug ID D0D1HA
NDC Product Code 0143-9933; 0143-9930; 0143-9935; 0143-9931
Synonyms Cefotaxime | Cephotaxim | Cefotaxim | Biosint | Cefotaxime Sodium | Sodium, Cefotaxime | Cefradil | Taporin | Fotexina | HR-756 | HR 756 | HR756 | Kendrick | Ru-24756 | Ru 24756 | Ru24756 | Benaxima | Claforan | Primafen | Klaforan
Chemical Information
Molecular Formula C16H17N5O7S2
CAS Registry Number 63527-52-6
SMILES CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Encephalopathy17.13.02.001--
Enterocolitis07.08.03.003--
Eosinophilia01.02.04.0010.000319%
Erythema23.03.06.0010.000213%Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.0030.000319%
Feeling abnormal08.01.09.014--Not Available
Gastrointestinal pain07.01.05.005--
Glucose urine13.13.02.016--Not Available
Haemoglobin13.01.05.018--Not Available
Haemolytic anaemia01.06.03.0020.000213%Not Available
Headache17.14.01.001--
Hepatic failure09.01.03.0020.000056%
Hepatic function abnormal09.01.02.001--Not Available
Hepatic necrosis09.01.07.0020.000213%
Hepatitis09.01.07.0040.000213%Not Available
Hepatocellular injury09.01.07.0080.000532%Not Available
Hypersensitivity10.01.03.003--
Hypotension24.06.03.0020.000319%
Injection site inflammation12.07.03.009; 08.02.03.008--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Leukopenia01.02.02.0010.000319%Not Available
Local reaction08.01.03.012--Not Available
Loss of consciousness17.02.04.0040.000319%Not Available
Malaise08.01.01.003--
Nausea07.01.07.001--
Nephropathy toxic20.05.03.002; 12.03.01.010--Not Available
Neutropenia01.02.03.0040.000426%Not Available
Pain08.01.08.0040.000319%
Pancytopenia01.03.03.0030.000213%Not Available
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