Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cefazolin
Drug ID BADD_D00382
Description A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Indications and Usage Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
Marketing Status Prescription; Discontinued
ATC Code J01DB04
DrugBank ID DB01327
KEGG ID D02299
MeSH ID D002437
PubChem ID 33255
TTD Drug ID D09KDN
NDC Product Code 71872-7141; 0781-3450; 50090-4256; 44567-706; 72572-055; 71872-7027; 0143-9665; 0404-9833; 67184-1001; 0143-9924; 0143-9983; 60505-6142; 52584-923; 0143-9261; 44567-707; 0781-3452; 0781-3451; 70518-3047; 67184-0560; 17337-0300; 0143-9262; 0404-9834; 52584-087; 0143-9923; 60505-6231; 52584-924; 44567-120; 0404-9835; 72572-056; 0409-2585; 60505-6143; 44567-708
Synonyms Cefazolin | Cephazolin | Cefamedin | Cefamezine | Cephamezine | Gramaxin | Kefzol | Totacef | Ancef | Cefazolin Sodium | Sodium, Cefazolin | Sodium Cephazolin | Cephazolin, Sodium | Cephazolin Sodium | Sodium, Cephazolin
Chemical Information
Molecular Formula C14H14N8O4S3
CAS Registry Number 25953-19-9
SMILES CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Serratia infection11.02.25.0010.000319%Not Available
Blood disorder01.05.01.004--Not Available
Renal impairment20.01.03.0100.000213%Not Available
Hepatic enzyme abnormal13.03.01.0200.002023%Not Available
Bone marrow failure01.03.03.0050.000319%
Treatment failure08.06.01.0170.000056%Not Available
Post procedural infection12.02.05.010; 11.01.08.019--Not Available
Anal pruritus07.03.03.002--Not Available
Anorectal discomfort07.03.03.003--Not Available
Kounis syndrome24.04.04.020; 10.01.03.037; 02.02.02.0200.000745%Not Available
Acute kidney injury20.01.03.0160.001490%
Noninfectious peritonitis07.07.01.0050.000213%Not Available
Drug-induced liver injury12.03.01.044; 09.01.07.0230.003406%Not Available
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.0210.000213%Not Available
Candida infection11.03.03.021--
Antiphospholipid syndrome24.01.01.029; 18.02.04.002; 10.04.01.009; 01.01.02.0160.000213%Not Available
Clostridium difficile infection11.02.02.0090.000319%Not Available
Necrotising oesophagitis07.04.05.0060.000213%Not Available
Antibiotic level above therapeutic13.17.01.0150.000213%Not Available
Serratia test positive13.08.01.0140.000213%Not Available
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