Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Caspofungin acetate
Drug ID BADD_D00377
Description Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal cell wall.
Indications and Usage For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.
Marketing Status Prescription
ATC Code J02AX04
DrugBank ID DB00520
KEGG ID D02501
MeSH ID D000077336
PubChem ID 6850808
TTD Drug ID D00ZCN
NDC Product Code 63323-356; 0006-3822; 69097-366; 14474-037; 62227-022; 70860-107; 68083-159; 72611-702; 0781-3423; 68083-158; 69806-0092; 72843-533; 69097-365; 69766-064; 70860-106; 0006-3823; 63323-358; 72266-106; 57884-0030; 72843-434; 72266-107; 0781-3421; 52076-6230; 72611-700
Synonyms Caspofungin | Cancidas | MK 0991 | MK-0991 | MK0991 | Caspofungin MSD | L 743,872 | L-743,872 | L743,872 | L-743872 | L743872 | L 743872 | Caspofungin Acetate
Chemical Information
Molecular Formula C56H96N10O19
CAS Registry Number 179463-17-3
SMILES CCC(C)CC(C)CCCCCCCCC(=O)NC1CC(C(NC(=O)C2C(CCN2C(=O)C(NC(=O)C(NC(=O)C3CC(CN3C(=O) C(NC1=O)C(C)O)O)C(C(C4=CC=C(C=C4)O)O)O)C(CCN)O)O)NCCN)O.CC(=O)O.CC(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Diarrhoea07.02.01.001--
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Epistaxis24.07.01.005; 22.04.03.001--
Erythema23.03.06.001--Not Available
Erythema multiforme10.01.03.015; 23.03.01.003--
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.002--
Fluid overload14.05.06.001; 02.05.04.004--Not Available
Flushing23.06.05.003; 08.01.03.025; 24.03.01.002--
Haematocrit decreased13.01.05.001--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin decreased13.01.05.003--Not Available
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hepatic necrosis09.01.07.002--
Hepatomegaly09.01.05.001--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.003--Not Available
Hypercalcaemia14.04.01.003; 05.04.01.002--
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hypertension24.08.02.001--
Hypokalaemia14.05.03.002--
Hypomagnesaemia14.04.02.001--
Hypotension24.06.03.002--
Hypoxia22.02.02.003--
Insomnia19.02.01.002; 17.15.03.002--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Mucosal inflammation08.01.06.002--Not Available
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