Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carmustine
Drug ID BADD_D00371
Description A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Indications and Usage For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
Marketing Status Prescription
ATC Code L01AD01
DrugBank ID DB00262
KEGG ID D00254
MeSH ID D002330
PubChem ID 2578
TTD Drug ID D01OXI
NDC Product Code 70121-1482; 50683-0017; 76339-121; 0781-3474; 59651-168; 24338-050; 68475-503; 54893-0055; 23155-649; 57821-002; 55718-139; 23155-790; 43598-628; 59981-034; 70710-1525; 58621-002; 57884-0032; 54879-036; 23155-261; 71288-126
Synonyms Carmustine | BCNU | N,N'-Bis(2-Chloroethyl)-N-Nitrosourea | FIVB | 1,3-Bis(2-Chloroethyl)-1-Nitrosourea | BiCNU | Nitrumon
Chemical Information
Molecular Formula C5H9Cl2N3O2
CAS Registry Number 154-93-8
SMILES C(CCl)NC(=O)N(CCCl)N=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
GliomaMethylated-DNA--protein-cysteine methyltransferaseP16455T2458711070098; 15297393; 12744471
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Personality disorder19.05.02.002--Not Available
Phlebitis24.05.03.001; 12.02.01.002--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumonia aspiration22.01.01.005--Not Available
Pulmonary embolism24.01.06.001; 22.06.02.0010.001066%Not Available
Pulmonary fibrosis22.01.02.006--
Pulmonary hypoplasia22.10.01.002; 03.16.01.003--Not Available
Pupils unequal17.02.11.005; 06.05.03.0050.000533%Not Available
Pyrexia08.05.02.0030.002398%
Rash23.03.13.001--Not Available
Renal failure20.01.03.005--Not Available
Retinal haemorrhage24.07.05.003; 06.10.01.001--Not Available
Seizure17.12.03.0010.002398%
Sepsis11.01.11.0030.000208%
Skin exfoliation23.03.07.003--Not Available
Skin hyperpigmentation23.05.01.003--
Skin necrosis23.03.03.011--Not Available
Somnolence17.02.04.006; 19.02.05.0030.001332%
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.003--Not Available
Stomatitis07.05.06.005--
Stupor19.02.05.004; 17.02.04.007--Not Available
Subdural haematoma24.07.04.005; 17.08.05.002; 12.01.10.0030.000278%Not Available
Swelling08.01.03.015--Not Available
Tachycardia02.03.02.007--Not Available
Teratogenicity12.03.01.032; 03.02.01.004--Not Available
Thinking abnormal17.02.05.023; 19.10.03.001--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombophlebitis24.01.02.001--Not Available
Thrombosis24.01.01.006--Not Available
Tremor17.01.06.002--
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