Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carmustine
Drug ID BADD_D00371
Description A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Indications and Usage For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
Marketing Status Prescription
ATC Code L01AD01
DrugBank ID DB00262
KEGG ID D00254
MeSH ID D002330
PubChem ID 2578
TTD Drug ID D01OXI
NDC Product Code 70121-1482; 50683-0017; 76339-121; 0781-3474; 59651-168; 24338-050; 68475-503; 54893-0055; 23155-649; 57821-002; 55718-139; 23155-790; 43598-628; 59981-034; 70710-1525; 58621-002; 57884-0032; 54879-036; 23155-261; 71288-126
Synonyms Carmustine | BCNU | N,N'-Bis(2-Chloroethyl)-N-Nitrosourea | FIVB | 1,3-Bis(2-Chloroethyl)-1-Nitrosourea | BiCNU | Nitrumon
Chemical Information
Molecular Formula C5H9Cl2N3O2
CAS Registry Number 154-93-8
SMILES C(CCl)NC(=O)N(CCCl)N=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
GliomaMethylated-DNA--protein-cysteine methyltransferaseP16455T2458711070098; 15297393; 12744471
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Coordination abnormal17.02.02.004--Not Available
Cushing's syndrome24.08.04.001; 19.07.03.002; 14.11.01.007; 05.01.01.001--Not Available
Cyst08.03.05.001; 16.02.02.0020.000799%Not Available
Death08.04.01.001--
Depressed level of consciousness17.02.04.0020.001066%
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.001--
Diplopia06.02.06.002; 17.17.01.005--Not Available
Dizziness17.02.05.003; 24.06.02.007; 02.01.02.004--
Drug interaction08.06.03.001--Not Available
Dysphagia07.01.06.003--
Dyspnoea22.02.01.004; 02.01.03.002--
Encephalopathy17.13.02.001--
Epilepsy17.12.03.0020.000533%Not Available
Erythema23.03.06.001--Not Available
Extravasation08.01.03.008--Not Available
Eye disorder06.08.03.001--Not Available
Eye pain06.08.03.002--
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Facial paralysis17.04.03.008--Not Available
Febrile neutropenia08.05.02.004; 01.02.03.002--
Feeling abnormal08.01.09.014--Not Available
Fibrosis08.03.01.001--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gait disturbance08.01.02.002; 17.02.05.0160.000799%
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
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