Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carisoprodol
Drug ID BADD_D00370
Description Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications [A176047]. This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with both aspirin and codeine [FDA label, F4060, F4069]. In January 2012, this drug was classified as a Schedule IV substance under the controlled substances act in several US states due to alarming rates of abuse [A176062, A176077] despite having a low potential for abuse in addition to a low risk of dependence [L5074].
Indications and Usage For the relief of discomfort associated with acute, painful, musculoskeletal conditions.
Marketing Status Prescription; Discontinued
ATC Code M03BA02
DrugBank ID DB00395
KEGG ID D00768
MeSH ID D002328
PubChem ID 2576
TTD Drug ID D05PLH
NDC Product Code 70518-2800; 72789-019; 64980-380; 52286-0021; 50090-3232; 42543-700; 17337-0406; 50228-109; 76333-135; 63629-1168; 17381-080; 52536-682; 0037-2001; 0591-5513; 43353-102; 65862-158; 50090-5953; 68071-4610; 50090-5955; 62756-808; 71610-531; 72189-310; 77777-112; 50090-5214; 50090-4263; 71335-0693; 63187-786; 70518-3131; 63629-1167; 16571-780; 63629-8477; 71335-1203; 50090-4261; 55700-907; 50090-4746; 69584-111; 29033-207; 55700-954; 49452-1761; 29033-214; 55700-836; 60429-508; 0037-2250; 63629-1169; 55289-049; 70934-663; 60760-397; 71205-339; 63629-8478; 65862-260; 63629-8479; 71610-617; 63629-8202; 50090-5212; 65862-693; 58657-645; 60760-705; 55700-770; 16571-781; 50742-656; 66064-5001; 61919-878; 0143-1176; 63629-9144; 51525-5901; 52536-688; 45865-984; 63629-2416; 50090-3048; 71205-241; 71610-097; 51927-3169; 72789-016; 16714-510; 63629-9145; 50090-4744; 68071-5075; 43063-824; 71610-430; 70518-2618; 67296-1404; 64980-381; 72789-190; 72789-182; 72643-017; 63629-4707
Synonyms Carisoprodol | Isopropylmeprobamate | Isomeprobamate | Carisoprodate | Isobamate | Carisoma | Mio Relax | Soma | Vanadom | Soprodol | Somalgit
Chemical Information
Molecular Formula C12H24N2O4
CAS Registry Number 78-44-4
SMILES CCCC(C)(COC(=O)N)COC(=O)NC(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation17.02.05.012; 19.06.02.0010.001440%
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000864%
Anaphylactoid reaction24.06.03.007; 10.01.07.0030.000150%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Back pain15.03.04.005--
Cardiac arrest02.03.04.0010.001878%
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.001052%Not Available
Coma17.02.09.0010.000451%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.004657%Not Available
Cyanosis02.01.02.002; 24.03.01.007; 22.02.02.0070.000864%
Death08.04.01.0010.000901%
Delusion19.10.01.0010.000864%
Depressed level of consciousness17.02.04.0020.000864%
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug abuse19.07.02.0100.001577%Not Available
Drug dependence19.07.02.0090.001728%Not Available
Drug hypersensitivity10.01.01.0010.004895%Not Available
Drug withdrawal syndrome19.07.02.011; 08.06.02.0040.002016%Not Available
Dyspepsia07.01.02.001--
Feeling abnormal08.01.09.0140.001152%Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Headache17.14.01.001--
Hiccups22.02.04.002; 07.01.06.009--
Hypersensitivity10.01.03.0030.000864%
Hypertension24.08.02.0010.000576%
Hypotension24.06.03.0020.000864%
Hypoxia22.02.02.0030.000864%
Insomnia17.15.03.002; 19.02.01.0020.000576%
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