Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carboplatin
Drug ID BADD_D00364
Description Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982.[A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Indications and Usage Carboplatin is indicated in combination with an established combination of chemotherapeutic agents for the initial treatment of advanced ovarian carcinoma.[L32253] Carboplatin is also indicated for the palliative treatment of ovarian carcinoma, recurrent after prior chemotherapy.[L32253]
Marketing Status approved
ATC Code L01XA02
DrugBank ID DB00958
KEGG ID D01363
MeSH ID D016190
PubChem ID 426756
TTD Drug ID D0X7HM
NDC Product Code 0703-4239; 55150-386; 63323-172; 68083-191; 63592-0271; 61703-339; 0703-4244; 0703-4246; 72659-863; 50742-447; 69448-005; 61703-600; 55150-334; 61703-262; 61703-360; 71288-100; 49812-0010; 16729-295; 55150-333; 61703-150; 68083-193; 68554-0084; 68083-190; 68083-192; 53104-7570; 54875-0002; 50742-448; 55150-335; 0703-4248
UNII BG3F62OND5
Synonyms Carboplatin | cis-Diammine(cyclobutanedicarboxylato)platinum II | CBDCA | Paraplatin | Paraplatine | Platinwas | Ribocarbo | Carboplat | Neocarbo | Carbosin | Carbotec | Ercar | JM-8 | JM 8 | JM8 | Nealorin | NSC-241240 | NSC 241240 | NSC241240 | Blastocarb
Chemical Information
Molecular Formula C6H12N2O4Pt
CAS Registry Number 41575-94-4
SMILES C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Glioblastoma17.20.02.002; 16.30.02.0020.000112%Not Available
Glioma17.20.01.004; 16.30.01.0040.000728%Not Available
Granulocytopenia01.02.03.0030.000224%Not Available
Granulocytosis01.02.01.0080.000112%Not Available
Groin pain15.03.02.0040.000392%Not Available
Guillain-Barre syndrome17.09.01.001; 11.07.01.001; 10.04.10.0050.000112%
Haematemesis24.07.02.011; 07.12.02.0020.000560%Not Available
Haematoma24.07.01.0010.000672%
Haematuria21.10.01.018; 24.07.01.047; 20.02.01.0060.001511%
Haemoglobin13.01.05.018--Not Available
Haemoglobinaemia01.06.04.0010.000168%Not Available
Haemolysis01.06.04.0020.000280%
Haemolytic anaemia01.06.03.0020.001231%Not Available
Haemolytic uraemic syndrome20.01.03.011; 01.06.02.0010.000224%
Haemoptysis02.11.04.009; 22.02.03.004; 24.07.01.0060.000895%Not Available
Hair colour changes23.02.06.0010.000358%
Hair disorder23.02.06.0030.000302%Not Available
Hair texture abnormal23.02.06.0040.000470%
Hemiparesis17.01.04.0010.000280%
Hepatitis09.01.07.004--Not Available
Hepatitis cholestatic09.01.01.0020.000168%Not Available
Hepatomegaly09.01.05.0010.000112%Not Available
Hepatorenal failure20.01.03.013; 09.01.03.0080.000168%Not Available
Hepatotoxicity09.01.07.009; 12.03.01.008--Not Available
Hiccups22.12.01.001; 07.01.06.0090.000168%
Hydrocephalus17.07.01.0010.000616%
Hydronephrosis20.01.05.0010.001086%Not Available
Hyperaemia24.03.02.0020.000224%Not Available
Hyperaesthesia23.03.03.080; 17.02.06.0040.000168%Not Available
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.0030.000526%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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