Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carboplatin
Drug ID BADD_D00364
Description Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982.[A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Indications and Usage For the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimen consists of PARAPLATIN and cyclophosphamide. It is also indicated for the palliative treatment of patients with ovarian carcinoma recurrent after prior chemotherapy, including patients who have been previously treated with cisplatin.
Marketing Status Prescription; Discontinued
ATC Code L01XA02
DrugBank ID DB00958
KEGG ID D01363
MeSH ID D016190
PubChem ID 426756
TTD Drug ID D0X7HM
NDC Product Code 0703-4239; 55150-335; 63592-0271; 68083-192; 49812-0010; 68554-0084; 53104-7570; 69448-005; 0703-4246; 54875-0002; 55150-386; 55150-334; 0703-4248; 55150-333; 63323-172; 72659-863; 68083-191; 71288-100; 16729-295; 0703-4244; 68083-193; 68083-190; 61703-339
Synonyms Carboplatin | cis-Diammine(cyclobutanedicarboxylato)platinum II | CBDCA | Paraplatin | Paraplatine | Platinwas | Ribocarbo | Carboplat | Neocarbo | Carbosin | Carbotec | Ercar | JM-8 | JM 8 | JM8 | Nealorin | NSC-241240 | NSC 241240 | NSC241240 | Blastocarb
Chemical Information
Molecular Formula C6H12N2O4Pt
CAS Registry Number 41575-94-4
SMILES C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Liver disorder09.01.08.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Loss of consciousness17.02.04.0040.017050%Not Available
Lower respiratory tract infection22.07.01.002; 11.01.09.002--Not Available
Lung abscess22.07.01.006; 11.01.09.0060.000533%Not Available
Lung consolidation22.01.02.0100.001598%Not Available
Lung disorder22.02.07.001--Not Available
Lung infiltration22.01.02.0040.000799%Not Available
Lymphadenopathy01.09.01.0020.001598%Not Available
Lymphocyte count decreased13.01.06.0060.002931%
Lymphoma16.20.01.001; 01.12.01.001--Not Available
Lymphopenia01.02.02.0020.001066%Not Available
Malaise08.01.01.0030.025043%
Mass08.03.05.0030.001066%Not Available
Metabolic acidosis14.01.01.003--Not Available
Metastases to liver16.22.02.001; 09.04.02.0040.000556%Not Available
Metastases to lung22.08.01.005; 16.22.02.0020.000208%Not Available
Metastases to spine16.22.02.007; 15.09.03.0070.000533%Not Available
Microangiopathic haemolytic anaemia01.06.02.002; 24.03.02.0190.000139%Not Available
Micturition urgency20.02.02.0060.001332%
Migraine24.03.05.003; 17.14.02.001--Not Available
Mitral valve incompetence02.07.01.0020.000799%Not Available
Mouth ulceration07.05.06.004--Not Available
Mucosal inflammation08.01.06.0020.000903%Not Available
Muscle rigidity17.05.02.005; 15.05.04.001--Not Available
Muscle spasms15.05.03.004--
Muscle spasticity17.05.03.007; 15.05.04.0110.000799%
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.0070.002664%
Myalgia15.05.02.0010.006127%
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