Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cabergoline
Drug ID BADD_D00329
Description Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Indications and Usage For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.
Marketing Status Prescription; Discontinued
ATC Code G02CB03; N04BC06
DrugBank ID DB00248
KEGG ID D00987
MeSH ID D000077465
PubChem ID 54746
TTD Drug ID D04EGX
NDC Product Code 40016-011; 49884-673; 14096-153; 50090-3951; 47848-009; 50742-118; 50090-3157; 59762-1005; 50090-5834; 0093-5420
Synonyms Cabergoline | 1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea | FCE 21336 | FCE-21336 | Cabaser | Cabaseril | Dostinex | Galastop | Cabergoline Diphosphate | 1-Ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
Chemical Information
Molecular Formula C26H37N5O2
CAS Registry Number 81409-90-7
SMILES CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Iron deficiency14.13.02.0020.022020%Not Available
Irritability08.01.03.011; 19.04.02.0130.033030%
Joint dislocation15.01.07.002; 12.04.02.0070.022020%Not Available
Learning disability19.21.05.0020.022020%Not Available
Libido increased21.03.02.007; 19.08.03.0020.033030%
Liver abscess09.01.11.001; 11.01.18.0010.022020%Not Available
Liver function test abnormal13.03.01.013--Not Available
Loss of consciousness17.02.04.0040.055051%Not Available
Malaise08.01.01.0030.143131%
Mania19.16.02.0020.088081%
Memory impairment19.20.01.003; 17.03.02.0030.022020%
Menopausal symptoms21.02.02.002--Not Available
Mental disability26.01.01.001--Not Available
Mental impairment17.03.03.002; 19.21.02.003--Not Available
Mitral valve incompetence02.07.01.0020.077071%Not Available
Mood altered19.04.02.0070.022020%Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.0010.022020%
Musculoskeletal pain15.03.04.0070.044040%
Myocardial infarction24.04.04.009; 02.02.02.007--
Nasal congestion22.04.04.001--
Nasopharyngitis11.01.13.002; 22.07.03.0020.022020%Not Available
Nausea07.01.07.001--
Neck pain15.03.04.0090.022020%
Neoplasm16.16.02.0010.005744%Not Available
Neoplasm malignant16.16.01.001--Not Available
Nephrolithiasis20.04.01.0020.044040%
Nervousness19.06.02.0030.044040%Not Available
Neutropenia01.02.03.0040.066061%Not Available
Nightmare19.02.03.003--Not Available
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