Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cabergoline
Drug ID BADD_D00329
Description Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Indications and Usage For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.
Marketing Status Prescription; Discontinued
ATC Code G02CB03; N04BC06
DrugBank ID DB00248
KEGG ID D00987
MeSH ID D000077465
PubChem ID 54746
TTD Drug ID D04EGX
NDC Product Code 40016-011; 49884-673; 14096-153; 50090-3951; 47848-009; 50742-118; 50090-3157; 59762-1005; 50090-5834; 0093-5420
Synonyms Cabergoline | 1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea | FCE 21336 | FCE-21336 | Cabaser | Cabaseril | Dostinex | Galastop | Cabergoline Diphosphate | 1-Ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
Chemical Information
Molecular Formula C26H37N5O2
CAS Registry Number 81409-90-7
SMILES CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Depressed level of consciousness17.02.04.0020.022020%
Depressed mood19.15.02.0010.088081%Not Available
Depression19.15.01.0010.055051%
Dermatitis23.03.04.002--Not Available
Developmental delay08.01.03.0370.022020%Not Available
Diabetes insipidus05.03.03.004; 14.05.07.0030.022020%Not Available
Diabetes mellitus14.06.01.001; 05.06.01.0010.044040%Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Disturbance in attention19.21.02.002; 17.03.03.0010.033030%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug dependence19.07.02.0090.022020%Not Available
Drug hypersensitivity10.01.01.001--Not Available
Dry mouth07.06.01.0020.022020%
Duodenal ulcer07.04.02.002--
Duodenal ulcer perforation07.04.02.0030.005744%Not Available
Dyskinesia17.01.02.006--
Dysmenorrhoea21.01.01.002--
Dyspepsia07.01.02.0010.022020%
Dyspnoea22.02.01.004; 02.01.03.002--
Eating disorder19.09.01.008; 14.03.01.0080.022020%Not Available
Epilepsy17.12.03.0020.033030%Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Euphoric mood19.04.02.006--
Face oedema08.01.07.003; 23.04.01.004; 10.01.05.002--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.044040%Not Available
Fibrosis08.03.01.0010.022020%Not Available
Flatulence07.01.04.002--
Gait disturbance17.02.05.016; 08.01.02.0020.044040%
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