| Drug Name |
Buspirone hydrochloride |
| Drug ID |
BADD_D00317 |
| Description |
Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class,[A180991] buspirone is a serotonin 5-HT1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs.[L4478] Unlike many drugs used to treat anxiety, buspirone does not exhibit anticonvulsant, sedative, hypnotic, and muscle-relaxant properties. Due to these characteristics, buspirone been termed 'anxioselective'.[A180985] First synthesized in 1968 then patented in 1975,[L7375] it is commonly marketed under the brand name Buspar®. Buspirone was first approved in 1986 by the FDA [A181751] and has been used to treat anxiety disorders, such as generalized anxiety disorder (GAD), and relieve symptoms of anxiety. It has also been used as a second-line therapy for unipolar depression when the use of selective serotonin reuptake inhibitors (SSRIs) is deemed clinically inadequate or inappropriate.[L7375] The potential use of buspirone in combination with [melatonin] in depression and cognitive impairment via promoting neurogenesis has also been investigated.[A181751] |
| Indications and Usage |
For the management of anxiety disorders or the short-term relief of the symptoms of anxiety, and also as an augmention of SSRI-treatment against depression. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
N05BE01 |
| DrugBank ID |
DB00490
|
| KEGG ID |
D00702
|
| MeSH ID |
D002065
|
| PubChem ID |
36431
|
| TTD Drug ID |
D0U2OO
|
| NDC Product Code |
63187-221; 71335-1560; 70518-1050; 71335-1673; 55111-472; 63629-2409; 42291-176; 29300-244; 29300-247; 63187-402; 71610-342; 50090-2111; 50090-5347; 42806-082; 70518-3165; 29300-246; 71610-604; 68071-2572; 50090-4862; 70518-3065; 71335-1749; 50090-4182; 42806-085; 59651-393; 42806-662; 64380-742; 24689-785; 72888-063; 68788-7571; 68788-7462; 23155-097; 64380-743; 50090-5762; 0378-1150; 75834-270; 71335-1752; 70934-327; 42543-742; 68382-181; 55111-474; 51407-378; 69584-093; 55700-881; 43063-785; 71335-1608; 69238-1117; 29300-245; 63629-2411; 63629-3333; 55700-869; 63187-904; 50090-5405; 64380-787; 71610-299; 71610-208; 61919-579; 59651-392; 68382-183; 70518-0682; 68382-182; 0904-6899; 53747-040; 71610-640; 55700-526; 69117-0041; 63629-2414; 72888-066; 70518-1530; 0093-0053; 64380-744; 0615-7718; 42806-665; 70518-2303; 68788-7885; 51079-960; 70518-1924; 63629-6817; 50268-135; 70518-1404; 42543-744; 69238-1118; 55154-5397; 24689-907; 59651-389; 72789-141; 63629-6818; 42806-083; 64380-741; 50090-5797; 75834-267; 55154-5494; 16729-203; 24689-921; 65841-784; 69238-1116; 50090-3168; 53808-1102; 0615-7714; 63629-2413; 68788-8086; 51407-414; 51407-417; 69584-092; 63187-645; 23155-024; 0378-1140; 70518-0680; 59651-390; 71610-203; 71335-0991; 70518-2724; 51407-201; 51407-202; 71610-267; 71610-596; 51407-203; 12780-2940; 71610-344; 51407-377; 53002-1017; 55111-473; 63629-2410; 63629-2412; 60760-548; 71610-206; 49884-725; 69117-0042; 51407-415; 55111-475; 70518-2803; 53002-1424; 16729-202; 58118-0742; 71205-493; 50090-5886; 69117-0043; 42543-743; 70518-2987; 70934-198; 70518-0681; 0093-1003; 51079-986; 71335-0222; 70518-3091; 70518-2977; 61919-166; 67296-1520; 50090-5136; 70934-426; 50090-3260; 53002-5017; 71335-0562; 42291-177; 72789-142; 0378-1165; 68788-7968; 72789-181; 70518-3279; 59651-391; 63629-2415; 71610-302; 68788-7017; 0093-0054; 72189-175; 65841-782; 69584-094; 42543-787; 70518-2300; 70518-0380; 70934-184; 42806-084; 42806-664; 0093-5200; 70518-2031; 16729-200; 63629-7277; 75834-268; 23155-025; 0904-7121; 68071-3229; 51079-985; 43353-060; 71610-291; 24689-933; 71610-165; 71335-1938; 55154-3364; 42806-086; 70518-2830; 68788-7875; 72888-062; 50090-4657; 71205-280; 24689-781; 71335-1105; 68788-7952; 51927-3399; 72888-065; 69584-091; 70518-2660; 71610-487; 50090-4859; 0904-7122; 69238-1119; 70518-0401; 71335-1930; 72789-140; 71335-1144; 49452-1310; 16729-289; 69238-1115; 71335-2060; 67046-558; 63629-2408; 71335-0272; 0378-1145; 71610-307; 55700-837; 0378-1175; 71610-281; 68382-180; 67296-0925; 71610-266; 70518-2591; 71335-0552; 65841-783; 68071-3336; 75834-266; 68788-6984; 23155-023; 69117-0040; 71610-360; 42806-663; 71610-404; 72888-064; 42543-741; 71610-183; 70518-1981; 50090-5614; 51079-994; 51407-413; 51407-416; 55700-937; 71335-1924; 71335-1390; 65841-781; 0615-7689; 71335-0985; 71335-1605; 71610-608; 72789-139; 72189-200; 16729-201; 51927-0169; 70518-3382; 75834-269; 71610-257 |
| Synonyms |
Buspirone | N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide | Buspirone Hydrochloride | Hydrochloride, Buspirone | Gen-Buspirone | Gen Buspirone | Lin-Buspirone | Lin Buspirone | MJ-9022-1 | MJ 9022 1 | MJ90221 | Neurosine | Busp | Nu-Buspirone | Nu Buspirone | PMS-Buspirone | PMS Buspirone | Ratio-Buspirone | Ratio Buspirone | Anxut | Apo-Buspirone | Apo Buspirone | Buspar | Bespar | Novo-Buspirone | Novo Buspirone |
