Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Brivaracetam
Drug ID BADD_D00297
Description Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam [A19184]. It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 [L760].
Indications and Usage Used as adjunctive therapy for partial-onset seizures in patients 16 years of age or older.
Marketing Status approved; investigational
ATC Code N03AX23
DrugBank ID DB05541
KEGG ID D08879
MeSH ID C482793
PubChem ID 9837243
TTD Drug ID D0CT4D
NDC Product Code 16812-009; 36998-0118; 50474-670; 50474-770; 50474-970; 52076-6268; 28877-0118; 71666-007; 50474-370; 82608-003; 50474-570; 64220-214; 69037-0055; 50474-470; 69766-031; 50474-870
UNII U863JGG2IA
Synonyms brivaracetam | 2-(2-oxo-4-propylpyrrolidin-1-yl)butanamide | (2S)-2-((4R)-2-oxo-4-propylpyrrolidin-1-yl)butanamide | 1-pyrrolidineacetamide, alpha-ethyl-2-oxo-4-propyl-, (alphaS,4R)- | UCB 34714 | UCB34714 | UCB-34714 | Briviact
Chemical Information
Molecular Formula C11H20N2O2
CAS Registry Number 357336-20-0
SMILES CCCC1CC(=O)N(C1)C(CC)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Drug ineffective08.06.01.0060.006326%Not Available
Dyspnoea02.11.05.003; 22.02.01.004--
Emotional disorder19.04.02.0050.000635%Not Available
Epilepsy17.12.03.0020.000374%Not Available
Euphoric mood19.04.02.0060.000423%
Fatigue08.01.01.002--
Gait disturbance15.03.05.013; 17.02.05.016; 08.01.02.002--
Generalised tonic-clonic seizure17.12.01.0020.000623%Not Available
Hallucination19.10.04.0030.001220%
Hallucination, visual19.10.04.0070.000336%Not Available
Hypersomnia19.02.05.001; 17.15.01.001--
Hypoaesthesia23.03.03.081; 17.02.06.0230.000635%Not Available
Hyponatraemia14.05.04.0020.000336%
Insomnia19.02.01.002; 17.15.03.0020.000710%
Intentional self-injury19.12.01.002; 12.01.08.0360.000498%Not Available
Irritability19.04.02.013; 08.01.03.0110.002403%
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukaemia16.01.03.001; 01.10.03.0010.000125%
Loss of consciousness17.02.04.0040.000187%Not Available
Malaise08.01.01.003--
Memory impairment19.20.01.003; 17.03.02.0030.000461%
Mental impairment19.21.02.003; 17.03.03.002--Not Available
Migraine24.03.05.003; 17.14.02.0010.000423%Not Available
Mood altered19.04.02.0070.000336%Not Available
Mood swings19.04.03.0010.000274%Not Available
Myoclonus17.02.05.0080.000486%Not Available
Nervousness19.06.02.0030.000125%Not Available
Nightmare19.02.03.0030.000274%Not Available
Nystagmus17.02.02.006; 06.05.02.006--
Paranoia19.05.01.005--Not Available
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