Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Brivaracetam
Drug ID BADD_D00297
Description Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam [A19184]. It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 [L760].
Indications and Usage Used as adjunctive therapy for partial-onset seizures in patients 16 years of age or older.
Marketing Status Prescription
ATC Code N03AX23
DrugBank ID DB05541
KEGG ID D08879
MeSH ID C482793
PubChem ID 9837243
TTD Drug ID D0CT4D
NDC Product Code 52076-6268; 50474-470; 69037-0055; 50474-370; 50474-870; 50474-670; 50474-770; 50474-570; 50474-970; 71666-007; 82608-003; 36998-0118; 69766-031; 16812-009
Synonyms brivaracetam | 2-(2-oxo-4-propylpyrrolidin-1-yl)butanamide | (2S)-2-((4R)-2-oxo-4-propylpyrrolidin-1-yl)butanamide | 1-pyrrolidineacetamide, alpha-ethyl-2-oxo-4-propyl-, (alphaS,4R)- | UCB 34714 | UCB34714 | UCB-34714 | Briviact
Chemical Information
Molecular Formula C11H20N2O2
CAS Registry Number 357336-20-0
SMILES CCCC1CC(=O)N(C1)C(CC)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Generalised tonic-clonic seizure17.12.01.0020.000845%Not Available
Hallucination19.10.02.0020.000845%
Hallucination, visual19.10.02.0040.000338%Not Available
Headache17.14.01.001--
Hypersomnia19.02.05.001; 17.15.01.001--
Hypoaesthesia17.02.06.0230.000507%Not Available
Insomnia19.02.01.002; 17.15.03.002--
Intentional self-injury19.12.01.002; 12.01.08.0360.000845%Not Available
Irritability08.01.03.011; 19.04.02.0130.001014%
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Loss of consciousness17.02.04.0040.000507%Not Available
Malaise08.01.01.003--
Memory impairment19.20.01.003; 17.03.02.0030.000338%
Migraine24.03.05.003; 17.14.02.0010.000338%Not Available
Mood altered19.04.02.007--Not Available
Mood swings19.04.03.001--Not Available
Myocardial infarction02.02.02.007; 24.04.04.009--
Myoclonus17.02.05.0080.000338%Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Nystagmus17.02.02.006; 06.05.02.006--
Paranoia19.05.01.005--Not Available
Personality change19.05.01.006; 17.02.05.0190.000507%
Petit mal epilepsy17.12.04.0010.000507%Not Available
Psychomotor hyperactivity19.11.02.003; 17.01.02.0110.000338%Not Available
Psychotic behaviour19.03.01.003--Not Available
Rash23.03.13.0010.002197%Not Available
Rash generalised23.03.13.0020.000338%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.000132%
Restlessness19.11.02.002; 17.02.05.021--
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