Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bosutinib
Drug ID BADD_D00286
Description Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Compared to other tyrosine kinase inhibitors, it has a more favourable hematologic toxicity profile. FDA approved on September 4, 2012.
Indications and Usage Treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapy in adult patients.
Marketing Status Not Available
ATC Code L01EA04
DrugBank ID DB06616
KEGG ID D03252
MeSH ID C471992
PubChem ID 5328940
TTD Drug ID D0OB0F
NDC Product Code 54893-0042; 54893-0048; 54893-0041; 46708-878
Synonyms bosutinib | SKI606 | SKI-606
Chemical Information
Molecular Formula C26H29Cl2N5O3
CAS Registry Number 380843-75-4
SMILES CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ear disorder04.03.01.001--Not Available
Ear infection11.01.05.001; 04.03.01.0060.000799%Not Available
Ear pain04.03.01.0030.000799%
Eating disorder19.09.01.008; 14.03.01.0080.000799%Not Available
Electrocardiogram QT prolonged13.14.05.004--
Electrolyte imbalance14.05.01.0020.000208%Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.0150.000799%
Eye pain06.08.03.002--
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.0030.000533%
Faeces discoloured07.01.03.0020.000799%Not Available
Fatigue08.01.01.0020.038363%
Febrile neutropenia08.05.02.004; 01.02.03.002--
Feeling abnormal08.01.09.0140.004529%Not Available
Feeling cold08.01.09.0080.000533%Not Available
Feeling hot08.01.09.0090.000799%Not Available
Flatulence07.01.04.0020.002131%
Fluid overload14.05.06.001; 02.05.04.0040.001066%Not Available
Fluid retention20.01.02.003; 14.05.06.0020.005595%Not Available
Fracture15.08.02.001; 12.04.02.0010.000533%
Fungal infection11.03.05.001--Not Available
Furuncle23.09.01.004; 11.02.05.0080.000533%Not Available
Gait disturbance17.02.05.016; 08.01.02.0020.002664%
Gamma-glutamyltransferase increased13.03.01.0110.001066%
Gastric haemorrhage24.07.02.007; 07.12.01.001--
Gastric ulcer07.04.03.0020.001598%
Gastritis07.08.02.0010.000533%
Gastrooesophageal reflux disease07.02.02.0030.003197%
Gastroenteritis11.01.07.004; 07.19.03.0010.000533%Not Available
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