Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bosutinib
Drug ID BADD_D00286
Description Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Compared to other tyrosine kinase inhibitors, it has a more favourable hematologic toxicity profile. FDA approved on September 4, 2012.
Indications and Usage Treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapy in adult patients.
Marketing Status Not Available
ATC Code L01EA04
DrugBank ID DB06616
KEGG ID D03252
MeSH ID C471992
PubChem ID 5328940
TTD Drug ID D0OB0F
NDC Product Code 54893-0042; 54893-0048; 54893-0041; 46708-878
Synonyms bosutinib | SKI606 | SKI-606
Chemical Information
Molecular Formula C26H29Cl2N5O3
CAS Registry Number 380843-75-4
SMILES CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Atypical pneumonia22.07.01.010; 11.01.09.012--Not Available
Back pain15.03.04.0050.005062%
Blindness17.17.01.003; 06.02.02.0010.001066%Not Available
Blister23.03.01.001; 12.01.06.0020.001598%Not Available
Blood bilirubin increased13.03.01.008--
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine increased13.13.01.0040.003730%
Blood glucose increased13.02.02.002--Not Available
Blood pressure fluctuation24.06.01.0020.000799%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood urea increased13.13.01.0060.000533%Not Available
Blood uric acid increased13.02.04.0010.000799%Not Available
Body temperature increased13.15.01.0010.000533%Not Available
Bone pain15.02.01.0010.004263%
Bronchitis11.01.09.001; 22.07.01.0010.001332%
Burning sensation17.02.06.001; 08.01.09.0290.001066%Not Available
C-reactive protein increased13.09.01.007--Not Available
Cardiac failure02.05.01.0010.002085%
Cardiac failure acute02.05.01.0050.000533%Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiac tamponade02.06.01.0010.000533%
Cardiomegaly02.04.02.0010.000208%Not Available
Cellulitis23.09.01.001; 11.02.01.0010.001066%Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort08.01.08.019; 22.02.08.001; 02.02.02.0090.001598%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.003730%Not Available
Chills15.05.03.016; 08.01.09.0010.002131%
Chromaturia20.02.01.0020.000533%
Chronic myeloid leukaemia16.01.07.001; 01.10.07.0010.002571%Not Available
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