ADReCS

Pharmaceutical Information

Drug Name	Bisoprolol
Drug ID	BADD_D00277
Description	Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage	Bisoprolol is indicated for the treatment of mild to moderate hypertension.[L7219] It may be used off-label to treat heart failure, atrial fibrillation, and angina pectoris.[A180460,A180463]
Marketing Status	approved
ATC Code	C07AB07
DrugBank ID	DB00612
KEGG ID	D02342
MeSH ID	D017298
PubChem ID	2405
TTD Drug ID	D0K3ZR
NDC Product Code	Not Available
UNII	Y41JS2NL6U
Synonyms	Bisoprolol \| Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer \| Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer \| Bisoprolol Hydrochloride \| Hydrochloride, Bisoprolol \| Bisoprolol Methanesulfonate Salt \| Bisoprolol, (+-)-Isomer \| Bisoprolol, Fumarate (1:1) Salt \| Bisoprolol, Fumarate (2:1) Salt \| CL-297939 \| CL 297939 \| CL297939 \| Concor \| EMD-33512 \| EMD 33512 \| EMD33512 \| Bisoprolol Fumarate \| Fumarate, Bisoprolol \| Bisoprolol, (-)-Isomer

Chemical Information

Molecular Formula	C18H31NO4
CAS Registry Number	66722-44-9
SMILES	CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Stridor	22.04.02.003	-	-
Stupor	19.02.05.004; 17.02.04.007	0.000314%		Not Available
Subarachnoid haemorrhage	12.01.10.011; 24.07.04.004; 17.08.01.010	0.000785%		Not Available
Suicidal ideation	19.12.01.003	-	-
Suicide attempt	19.12.01.004	0.001884%
Supraventricular extrasystoles	02.03.03.011	0.000628%		Not Available
Supraventricular tachycardia	02.03.03.012	0.000785%
Swelling face	08.01.03.100; 23.04.01.018; 10.01.05.018	-	-	Not Available
Swollen tongue	10.01.05.015; 07.14.02.003; 23.04.01.014	0.000471%		Not Available
Syncope	02.11.04.015; 24.06.02.012; 17.02.04.008	0.013658%
Systemic lupus erythematosus	23.03.02.006; 15.06.02.003; 10.04.03.004	0.000785%		Not Available
Tachycardia	02.03.02.007	0.006562%		Not Available
Tachypnoea	22.02.01.014	0.000314%		Not Available
Tendon disorder	12.01.07.019; 15.07.01.002	0.000314%		Not Available
Tendonitis	12.01.07.007; 15.07.01.003	0.000628%		Not Available
Thirst	14.03.02.007; 08.01.09.021	0.000942%		Not Available
Throat tightness	22.12.03.031; 19.01.02.005	0.000471%		Not Available
Thrombocytopenia	01.08.01.002	0.003611%		Not Available
Thrombocytopenic purpura	23.06.01.007; 01.08.01.003	-	-	Not Available
Thyroid disorder	05.02.01.002	0.000314%		Not Available
Tinnitus	17.04.07.004; 04.04.01.002	0.001413%
Tongue oedema	23.04.01.009; 10.01.05.008; 07.14.02.007	0.000314%		Not Available
Torsade de pointes	02.03.04.005	0.000628%		Not Available
Toxic epidermal necrolysis	23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006	0.000314%
Tremor	17.01.06.002	-	-
Tricuspid valve incompetence	02.07.05.001	0.001413%		Not Available
Ulcer	08.03.06.001	0.000314%		Not Available
Unresponsive to stimuli	17.02.05.031	0.000942%		Not Available
Upper gastrointestinal haemorrhage	24.07.02.024; 07.12.02.006	0.001256%
Urinary incontinence	20.02.02.010; 17.05.01.008	0.001099%

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