Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol
Drug ID BADD_D00277
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage Bisoprolol is indicated for the treatment of mild to moderate hypertension.[L7219] It may be used off-label to treat heart failure, atrial fibrillation, and angina pectoris.[A180460,A180463]
Marketing Status approved
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D02342
MeSH ID D017298
PubChem ID 2405
TTD Drug ID D0K3ZR
NDC Product Code Not Available
UNII Y41JS2NL6U
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C18H31NO4
CAS Registry Number 66722-44-9
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain lower07.01.05.0100.001099%Not Available
Abdominal pain upper07.01.05.0030.002669%
Abdominal tenderness07.01.05.0040.000314%Not Available
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Actinic keratosis23.01.06.0010.000628%Not Available
Acute hepatic failure09.01.03.0010.000942%Not Available
Acute myocardial infarction02.02.02.001; 24.04.04.0010.001256%Not Available
Acute psychosis19.03.01.0010.000471%Not Available
Acute pulmonary oedema22.01.03.005; 02.05.02.0040.000785%Not Available
Acute respiratory failure22.02.06.001; 14.01.04.0040.000785%Not Available
Ageusia07.14.03.003; 17.02.07.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.0010.001256%Not Available
Akathisia17.01.02.002; 19.06.02.0060.000628%
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.0010.000785%Not Available
Amnesia17.03.02.001; 19.20.01.0010.001256%
Amyotrophic lateral sclerosis17.05.05.0040.000628%Not Available
Anaemia01.03.02.0010.004396%
Anaphylactic shock24.06.02.004; 10.01.07.0020.001413%Not Available
Angina pectoris24.04.04.002; 02.02.02.0020.001413%
Angina unstable02.02.02.004; 24.04.04.0040.000314%Not Available
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.0090.001884%Not Available
Anosmia22.04.03.006; 17.04.04.001--
Anuria20.01.03.0020.000628%Not Available
Anxiety19.06.02.002--
Aortic valve incompetence02.07.03.0010.000471%Not Available
Apathy19.04.04.0020.000628%Not Available
Aphasia19.21.01.001; 17.02.03.0010.001413%
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ADReCS-Target
Drug Name ADR Term Target
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