Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Betamethasone
Drug ID BADD_D00260
Description Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties.[A192444] It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders.[A192444] Betamethasone has potent glucocorticoid activity and negligible mineralocorticoid activity.[A192444]
Indications and Usage Systemic use: for the treatment of edocrine disorders, rheumatic disorders, collagen diseases, dermatological diseases, allergic states, ophthalmic diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, gastrointestinal diseases, tuberculous meningitis and trichinosis.
Marketing Status Discontinued
ATC Code A07EA04; C05AA05; D07AC01; D07XC01; H02AB01; R01AD06; R03BA04; S01BA06; S01CB04; S02BA07; S03BA03
DrugBank ID DB00443
KEGG ID D00244
MeSH ID D001623
PubChem ID 9782
TTD Drug ID D0CW1P
NDC Product Code 52128-166; 22552-0030; 64958-0012
Synonyms Betamethasone | Flubenisolone | Betadexamethasone | Celestona | Cellestoderm | Celeston | Celestone
Chemical Information
Molecular Formula C22H29FO5
CAS Registry Number 378-44-9
SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypertension24.08.02.0010.000594%
Hypertrichosis23.02.04.002--
Hypertrophic cardiomyopathy02.04.01.002; 03.07.02.004--Not Available
Hypokalaemic syndrome14.05.03.003--Not Available
Hypopituitarism05.03.02.001--
Hypotension24.06.03.002--
Impaired healing08.03.02.001--Not Available
Increased appetite08.01.09.027; 14.03.01.003--Not Available
Increased insulin requirement14.06.01.006; 05.06.01.006--Not Available
Infection11.01.08.002--Not Available
Infection susceptibility increased11.01.08.004; 10.02.01.046--Not Available
Injury12.01.08.004--Not Available
Insomnia17.15.03.002; 19.02.01.002--
Intracranial pressure increased17.07.02.002--Not Available
Intraocular pressure increased13.07.04.002--Not Available
Large intestine perforation12.02.03.005; 07.04.06.005--
Leukoderma23.05.02.001--Not Available
Loss of consciousness17.02.04.004--Not Available
Malaise08.01.01.003--
Meningitis17.06.03.001; 11.01.03.001--
Menstruation irregular21.01.01.005; 05.05.01.008--
Miliaria23.02.03.014--Not Available
Monoplegia17.01.04.003--Not Available
Mood swings19.04.03.001--Not Available
Muscle disorder15.05.03.014--Not Available
Muscular weakness15.05.06.001; 17.05.03.005--
Myasthenia gravis17.05.04.001; 15.05.08.001; 10.04.05.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Myocardial rupture12.01.11.002; 02.04.02.002--Not Available
Myopathy15.05.05.001--Not Available
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