Drug Name |
Benztropine |
Drug ID |
BADD_D00244 |
Description |
Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970. The generation of structure-activity relationships proved that benztropine derivatives with the presence of a chlorine substituent in the para position in one of the phenyl rings produces an increased potency for dopamine uptake inhibition as well as a decreased inhibition of serotonin and norepinephrine.[A37914] Benztropine was developed by USL Pharma and officially approved by the FDA on 1996.[L5500] |
Indications and Usage |
For use as an adjunct in the therapy of all forms of parkinsonism and also for use in the control of extrapyramidal disorders due to neuroleptic drugs. |
Marketing Status |
Prescription; Discontinued |
ATC Code |
N04AC01 |
DrugBank ID |
DB00245
|
KEGG ID |
D07511
|
MeSH ID |
D001590
|
PubChem ID |
1201549
|
TTD Drug ID |
D0HQ6N
|
NDC Product Code |
69097-827; 69097-832; 69097-826 |
Synonyms |
Benztropine | Benzatropine | Bensylate | Benzatropine Methanesulfonate | Methanesulfonate, Benzatropine | Benzatropine Mesylate | Mesylate, Benzatropine | Benztropine Mesylate | Mesylate, Benztropine | Benzatropine Methanesulfonate, Hydrobromide | Hydrobromide Benzatropine Methanesulfonate | Methanesulfonate, Hydrobromide Benzatropine | PMS-Benztropine | PMS Benztropine | Benzatropine Methanesulfonate, Hydrochloride, (endo)-Isomer | Cogentin | Cogentinol | N-Methylbenztropine | N Methylbenztropine | Apo-Benztropine | Apo Benztropine | Benzatropine Methanesulfonate, Hydrobromide, (endo)-Isomer |