Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Beclomethasone
Drug ID BADD_D00217
Description Beclomethasone dipropionate is a second-generation synthetic corticosteroid agent [A179842] and a diester of beclomethasone, which is structurally similar to [dexamethasone].[L6871] It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP)[A179839] which acts on the glucocorticoid receptor to mediates its therapeutic action. Beclomethasone dipropionate itself posesses weak glucocorticoid receptor binding affinity and is rapidly converted into 17-BMP upon administration.[A179839] Formulations for oral inhalation, intranasal, and topical use are available for beclomethasone dipropionate. Beclomethasone dipropionate became first available in a pressurized metered-dose inhaler in 1972 and later in a dry powder inhaler and an aqueous nasal spray.[A179839] Due to its anti-inflammatory, antipruritic, and anti-allergy properties, beclomethasone dipropionate is used in various inflammatory conditions, such as asthma, allergic rhinitis, and dermatoses to reduce symptoms. When inhaled, it is proposed that beclomethasone dipropionate remains active locally in the lung without causing significant side effects associated with systemic corticosteroids.[A180010] Compared to earlier corticosteroids such as [dexamethasone] and [prednisolone], beclomethasone dipropionate is reported to be less irritating to the nasal mucosa with a longer duration of action when administered intranasally.[A179848]
Indications and Usage Used in the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older, and in treating symptoms for allergic rhinitis (seasonal or perennial) in patients 12 years of age and older. Also being investigated for oral treatment in mild-to-moderate Crohn's disease of ileal or ileal-right colonic localisation and for "topical" use mild-to-moderate graft versus host disease.
Marketing Status Prescription; Discontinued
ATC Code A07EA07; D07AC15; R01AD01; R03BA01
DrugBank ID DB00394
KEGG ID D07495
MeSH ID D001507
PubChem ID 20469
NDC Product Code 22552-0038; 52128-167; 49452-0802; 51552-0883; 38779-0364; 59310-410; 51927-1641; 65089-0010; 53104-7632; 46439-8714; 52221-105; 59310-406
Synonyms Beclomethasone | Beclometasone | Asmabec Clickhaler | Ascocortonyl | Beclamet | Beclo Asma | Beclo AZU | Beclocort | Beclomet | Bemedrex Easyhaler | Beclomethasone Dipropionate | Dipropionate, Beclomethasone | Beclorhinol | Sanasthmax | Becloturmant | Beclovent | Beconase | Becloforte | Becodisk | Becodisks | Propaderm | Becotide | Sanasthmyl | Beconase AQ | Bronchocort | Junik | Qvar | Ecobec | Beclazone | Beclazone Easy Breathe | Ventolair | Prolair | Filair | Filair Forte | AeroBec Forte | Aerobec | Nasobec Aqueous | Respocort | Vancenase | Vanceril | Aldecin | Viarin | Apo-Beclomethasone
Chemical Information
Molecular Formula C22H29ClO5
CAS Registry Number 4419-39-0
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ageusia17.02.07.001; Available
Aggression19.05.01.001--Not Available
Anaphylactic shock24.06.02.004; Available
Angioedema23.04.01.001; Available
Asthma22.03.01.002; Available
Back pain15.03.04.005--
Dermatitis23.03.04.002--Not Available
Hyperadrenocorticism14.11.01.009;; Available
Impaired healing08.03.02.001--Not Available
Infection11.01.08.002--Not Available
Intraocular pressure increased13.07.04.002--Not Available
Lacrimation increased06.08.02.004--
Nasal congestion22.04.04.001--
Nasal septum perforation22.04.03.003--Not Available
Nasal septum ulceration22.04.03.016--Not Available
Nasopharyngitis22.07.03.002; Available
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