Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Baclofen
Drug ID BADD_D00209
Description Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant used for the relief of painful and uncomfortable muscle spasms caused by a variety of conditions. It is particularly useful in treating muscle spasticity associated with spinal cord injury. This drug has recently been studied for the management of alcohol withdrawal, however, a conclusion has not been made regarding baclofen efficacy in this condition. [A173908,A173911,A173938] This drug was first approved by the FDA in 1992.[F4570]
Indications and Usage For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity.
Marketing Status Prescription; Discontinued
ATC Code M03BX01
DrugBank ID DB00181
KEGG ID D00241
MeSH ID D001418
PubChem ID 2284
TTD Drug ID D01AJY
NDC Product Code 0527-1333; 80425-0112; 67457-563; 70771-1449; 72888-011; 52817-321; 68071-2414; 68071-4905; 55700-408; 60687-514; 45865-355; 70518-0362; 68788-7915; 50090-5855; 63629-6883; 61919-095; 68071-5252; 80425-0157; 68981-007; 70518-2662; 70511-121; 51927-0146; 0527-1330; 48954-469; 70511-124; 76420-931; 55700-403; 50090-1801; 70710-1609; 67457-564; 52817-319; 46014-1124; 71610-444; 70518-2173; 68055-946; 63629-1228; 70756-085; 50090-4682; 71335-0949; 50268-107; 72888-009; 51927-0147; 12658-0584; 63629-2128; 12658-0583; 0115-1011; 63629-2081; 10135-533; 60687-503; 68788-9246; 68084-868; 59651-394; 63629-3193; 65015-635; 67457-562; 53747-075; 65628-100; 71335-1797; 25021-680; 68134-401; 0615-3542; 70710-1286; 63275-9992; 63629-2131; 76420-930; 70771-1586; 55154-7635; 12658-0582; 0832-1054; 17511-130; 73320-001; 70257-562; 70257-414; 72888-010; 25021-681; 81371-6004; 50090-0564; 63629-2129; 61919-093; 71930-066; 43063-865; 31722-138; 50090-1650; 63629-2080; 16714-072; 70518-3089; 0615-8411; 59651-395; 68788-6384; 71610-614; 31722-999; 80425-0156; 50436-9022; 0615-8412; 46014-1035; 38779-3209; 71610-452; 50268-106; 29300-344; 71335-0103; 55289-757; 73320-003; 10135-532; 51552-0613; 71610-446; 71335-1356; 70518-3115; 70511-122; 70710-1285; 71930-006; 70756-289; 63629-1225; 65628-101; 0904-6475; 79572-003; 16714-071; 71525-010; 70518-2804; 70511-123; 63629-1226; 71610-391; 63629-2130; 71335-1664; 63187-313; 71335-0206; 68084-855; 63629-2083; 29300-343; 42291-158; 0115-1010; 52652-6001; 73320-002; 50090-5838; 38779-0388; 63629-1227; 71930-007; 68071-2289; 0172-4096; 25021-678; 62991-1013; 17856-0319; 43063-864; 63629-2082; 63187-280; 71335-1643; 50090-2871; 0603-2406; 0527-1337; 12658-0448; 68055-947; 68055-945; 50436-0060; 63629-1224; 68055-948; 70934-918; 63629-6406; 51927-2007; 0615-3541; 70257-416; 50218-010; 68071-3001; 61919-027; 70934-227; 0904-6476; 45865-452; 63187-274; 51014-7035; 52817-320; 55154-7876; 80425-0080; 80425-0081; 0395-8032; 63629-1286; 63739-480; 71525-040; 71525-005; 61919-026; 76420-165; 63739-479; 0115-1012; 70257-412; 67544-671; 31722-998; 0832-1055; 70771-1448; 68071-2420; 50268-105; 70756-288; 68071-3075; 0172-4097; 0603-2407; 50090-2493; 71335-0344; 71205-474; 69528-301; 49452-0807; 68071-5249; 25021-679; 72969-004; 63187-147; 71335-1796; 63629-2084
Synonyms Baclofen | Baclophen | PCP-GABA | beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid | Chlorophenyl GABA | GABA, Chlorophenyl | beta-(p-Chlorophenyl)-gamma-aminobutyric Acid | Clofen | Gen-Baclofen | Gen Baclofen | GenBaclofen | Genpharm | Apo-Baclofen | Apo Baclofen | ApoBaclofen | Atrofen | Baclofène-Irex | Baclofène Irex | BaclofèneIrex | Baclofen AWD | AWD, Baclofen | Lebic | Lioresal | Liorésal | Nu-Baclo | Nu Baclo | NuBaclo | PMS-Baclofen | PMS Baclofen | PMSBaclofen | Baclospas | Ba-34,647 | Ba34,647 | Ba-34647 | Ba34647 | CIBA-34,647-BA | CIBA34,647BA
Chemical Information
Molecular Formula C10H12ClNO2
CAS Registry Number 1134-47-0
SMILES C1=CC(=CC=C1C(CC(=O)O)CN)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Drug ineffectiveAdenosine receptor A1P30542T920729655623; 9080460; 8880852
Parkinson's diseaseTumor necrosis factorP16599Not Available25547370
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Drug hypersensitivity10.01.01.001--Not Available
Drug ineffective08.06.01.006--Not Available
Drug withdrawal convulsions17.12.03.016; 08.06.02.0030.000673%Not Available
Drug withdrawal syndrome19.07.02.011; 08.06.02.0040.063474%Not Available
Drug withdrawal syndrome neonatal19.07.02.012; 18.04.13.001; 08.06.02.0080.000673%Not Available
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dysaesthesia17.02.06.0030.000337%
Dysarthria17.02.08.001; 19.19.03.0010.001852%
Dysgeusia17.02.07.003; 07.14.03.001--
Dyskinesia17.01.02.0060.003872%
Dyspepsia07.01.02.001--
Dysphagia07.01.06.0030.004714%
Dysphoria19.04.02.004--Not Available
Dyspnoea02.01.03.002; 22.02.01.004--
Dystonia17.01.03.0010.006061%Not Available
Dysuria20.02.02.002--
Ear infection04.03.01.006; 11.01.05.001--Not Available
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.0010.000337%Not Available
Ejaculation disorder21.03.01.002--
Electrocardiogram QT prolonged13.14.05.004--
Electrocardiogram ST segment depression13.14.05.0050.000337%Not Available
Electroencephalogram abnormal13.07.03.0010.001684%Not Available
Encephalitis17.06.05.001; 11.01.03.0080.000505%
Encephalopathy17.13.02.0010.012627%
Enuresis20.02.02.003; 19.07.04.001--Not Available
Epilepsy17.12.03.0020.001347%Not Available
Erythema23.03.06.001--Not Available
Euphoric mood19.04.02.0060.005219%
Exostosis15.02.04.0050.000505%
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