Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Arformoterol tartrate
Drug ID BADD_D00160
Description Arformoterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing. Arformoterol inhalation is used to prevent bronchoconstriction in people with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema. The use of arformoterol is pending revision due to safety concerns in regards to an increased risk of severe exacerbation of asthma symptoms, leading to hospitalization as well as death in some patients using long acting beta agonists for the treatment of asthma.
Indications and Usage A bronchodilator used for the long term, symptomatic treatment of reversible bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.
Marketing Status Prescription; Discontinued
ATC Code R03AC13; R03CC15
DrugBank ID DB01274
KEGG ID D01373
MeSH ID D000068759
PubChem ID 9827062
TTD Drug ID D0D1DI
NDC Product Code 64567-0022; 53104-7731; 63402-911; 70748-257; 66039-909; 50384-4279; 68462-833; 69097-168; 14501-0077; 0093-5955
Synonyms Formoterol Fumarate | Formoterol Fumarate, ((R*,R*)-(+-))-isomer | 3-Formylamino-4-hydroxy-alpha-(N-1-methyl-2-p-methoxyphenethylaminomethyl)benzyl alcohol.hemifumarate | BD 40A | Formoterol | Eformoterol | Oxis | Arformoterol | Formoterol, ((R*,R*)-(+-))-isomer | Foradil
Chemical Information
Molecular Formula C23H30N2O10
CAS Registry Number 200815-49-2
SMILES CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O.C(C(C(=O)O)O)(C(=O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Eosinophilic disordersInterleukin-5P05113T78585Not Available
Eosinophilic disordersC-X-C motif chemokine 10P02778T30635Not Available
Surgical and medical proceduresBeta-2 adrenergic receptorP07550T52522Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abscess11.01.08.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Angina pectoris24.04.04.002; 02.02.02.002--
Arrhythmia02.03.02.001--Not Available
Arteriosclerosis24.04.02.001--Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Asthenia08.01.01.001--Not Available
Atrial flutter02.03.03.003--
Atrioventricular block02.03.01.002--Not Available
Back pain15.03.04.005--
Bone disorder15.02.04.004--Not Available
Breast neoplasm21.05.01.004; 16.10.02.001--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Cardiac failure congestive02.05.01.002--Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Constipation07.02.02.001--
Cystitis20.03.02.002; 11.01.14.001--
Dehydration14.05.05.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.004--
Dyspnoea22.02.01.004; 02.01.03.002--
Electrocardiogram QT prolonged13.14.05.004--
Electrocardiogram T wave inversion13.14.05.007--Not Available
Fatigue08.01.01.002--
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