Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. It has also been used to lower the risk of developing venous thrombosis post-orthopedic surgical procedures.
Marketing Status Prescription
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 65129-1344; 55111-980; 50193-0893; 63629-8432; 16436-0113; 70366-001; 46708-908; 52048-0420; 63850-8085; 42816-0893; 14445-150; 59651-051; 53747-062; 65015-897; 55154-0613; 66174-0091; 76397-007; 75945-060; 24196-190; 15308-1221; 12783-0894; 66651-921; 63415-0520; 70518-1861; 66039-925; 65372-1196; 55154-0612; 12783-0893; 69989-0006; 76397-010; 42765-025; 76072-1017; 14501-0089; 67835-0015; 69037-0023; 50090-1437; 0003-0894; 58623-0137; 0003-3764; 42816-0894; 67296-1673; 58032-2028; 50090-1436; 65727-081; 14445-014; 63629-7747; 14445-149
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Arrhythmia supraventricular02.03.03.0010.000265%Not Available
Arterial injury24.11.02.002; 12.01.11.0080.000265%
Arterial thrombosis24.01.01.0020.001722%Not Available
Arteriosclerosis24.04.02.001--Not Available
Arteriovenous fistula24.03.03.0010.000397%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Arthropathy15.01.01.0030.015235%Not Available
Ascites07.07.01.001; 02.05.04.002; 09.01.05.003--
Aspartate aminotransferase increased13.03.01.006--
Asphyxia22.02.02.001; 12.01.08.011--Not Available
Aspiration22.02.07.0070.000380%
Aspiration pleural cavity13.19.03.0020.001192%Not Available
Asthenia08.01.01.001--Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atelectasis22.01.02.001--
Atrial fibrillation02.03.03.0020.046367%
Atrial flutter02.03.03.0030.001987%
Atrial septal defect03.07.02.002; 02.04.02.009--Not Available
Atrial tachycardia02.03.03.0040.000265%
Atrioventricular block02.03.01.002--Not Available
Atrioventricular block complete02.03.01.003--
Autoimmune hepatitis10.04.09.001; 09.01.07.019--Not Available
Back disorder15.03.01.0140.002120%Not Available
Back pain15.03.04.005--
Bacteraemia11.01.11.001--
Barrett's oesophagus07.11.03.0020.000265%Not Available
Basal cell carcinoma23.08.02.001; 16.03.02.001--Not Available
Benign prostatic hyperplasia21.04.02.0010.001192%Not Available
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