Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alpha-1-proteinase inhibitor (human)
Drug ID BADD_D00084
Description Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.
Indications and Usage For chronic augmentation and maintenance therapy in individuals with alpha1-proteinase inhibitor (A1-PI) deficiency and clinical evidence of emphysema.
Marketing Status Not Available
ATC Code B02AB02
DrugBank ID DB00058
KEGG ID D11965
MeSH ID D000515
PubChem ID Not Available
TTD Drug ID D9EC0G
NDC Product Code 0944-2814; 13533-703; 13533-706; 0944-2815; 13533-700
Synonyms alpha 1-Antitrypsin | alpha 1 Antitrypsin | alpha 1 Antiprotease | Antiprotease, alpha 1 | Serpin A1 | alpha 1-Protease Inhibitor | Inhibitor, alpha 1-Protease | alpha 1 Protease Inhibitor | alpha 1-Proteinase Inhibitor | Inhibitor, alpha 1-Proteinase | alpha 1 Proteinase Inhibitor | Trypsin Inhibitor, alpha 1-Antitrypsin | Trypsin Inhibitor, alpha 1 Antitrypsin | A1PI | alpha 1-Antiproteinase | 1-Antiproteinase, alpha | alpha 1 Antiproteinase | Prolastin | Zemaira
Chemical Information
Molecular Formula Not Available
CAS Registry Number 9041-92-3
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Diabetes mellitusNot AvailableP58840Not AvailableNot Available
HyperglycaemiaNot AvailableP58840Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Back pain15.03.04.005--
Blood pressure increased13.14.03.005--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm22.03.01.004; 10.01.03.012--
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.003--Not Available
Chills15.05.03.016; 08.01.09.001--
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Cough22.02.03.001--
Diarrhoea07.02.01.001--
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Infection11.01.08.002--Not Available
Influenza like illness08.01.03.010--
Injection site haemorrhage08.02.03.005; 24.07.01.010; 12.07.03.005--Not Available
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
Injury12.01.08.004--Not Available
Lung disorder22.02.07.001--Not Available
Lung infiltration22.01.02.004--Not Available
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