Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pruritus23.03.12.001--
Pulmonary alveolar haemorrhage24.07.01.015; 22.01.02.0050.000044%Not Available
Pulmonary congestion02.05.02.002; 24.03.08.001; 22.01.03.0020.000044%Not Available
Pulmonary fibrosis22.01.02.0060.000396%
Pulmonary granuloma22.01.01.0140.000088%Not Available
Pulmonary hypertension24.08.03.002; 22.06.01.0010.000528%
Pulmonary valve incompetence02.07.04.0010.000044%Not Available
Pyoderma gangrenosum23.07.03.001; 16.32.03.005; 10.04.02.0090.000044%Not Available
Pyogenic granuloma23.10.01.001; 24.03.06.002; 16.26.01.001; 07.20.02.0040.000044%Not Available
Radiculopathy17.10.01.0050.000881%
Rash23.03.13.001--Not Available
Raynaud's phenomenon24.04.03.0030.000220%Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.0010.000352%
Rectal polyp16.05.02.003; 07.20.01.0050.000176%Not Available
Rectal prolapse07.03.01.0050.000044%Not Available
Rectocele21.07.05.005; 07.16.06.0030.000286%Not Available
Refraction disorder06.02.04.0040.000044%Not Available
Renal cyst20.01.04.001; 16.27.01.0010.000859%Not Available
Renal disorder20.01.02.0020.000198%Not Available
Renal failure20.01.03.0050.000726%Not Available
Renal haemorrhage24.07.07.002; 20.01.02.013; 12.01.05.0040.000110%
Renal pain20.02.03.0030.000097%Not Available
Renal tubular necrosis20.01.07.0030.000044%Not Available
Respiratory disorder22.02.07.0020.000154%Not Available
Respiratory distress22.02.01.0120.000132%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.000550%
Retinal degeneration06.09.03.0020.000066%Not Available
Retinal detachment12.01.04.004; 06.09.03.0030.000220%
Retinal disorder06.08.03.0050.000044%Not Available
Retinal tear12.01.04.014; 06.09.03.0100.000132%
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