Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alemtuzumab
Drug ID BADD_D00064
Description Humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein,CD52. The Campath-1H antibody is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). Campath is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium containing neomycin.
Indications and Usage Alemtuzumab (Campath) is a monoclonal antibody therapy used for treatment of B-cell chronic lymphocytic leukemia.
Marketing Status Prescription
ATC Code L04AA34
DrugBank ID DB00087
KEGG ID D02802
MeSH ID D000074323
PubChem ID Not Available
TTD Drug ID D01ZYG
NDC Product Code 58468-0200; 58468-0357
Synonyms Alemtuzumab | Campath 1H | Monoclonal Antibody Campath-1H | Antibody Campath-1H, Monoclonal | Campath-1H, Monoclonal Antibody | Monoclonal Antibody Campath 1H | Campath-1H | Campath1H | Campath 1M | Campath-1M | MabCambath | Lemtrada | Campath 1G | Campath-1-G | Campath 1 G | Campath1G | Campath-1G | Campath
Chemical Information
Molecular Formula Not Available
CAS Registry Number 216503-57-0
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Epistaxis24.07.01.005; 22.04.03.001--
Erythema23.03.06.001--Not Available
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Fungal infection11.03.05.001--Not Available
Goodpasture's syndrome10.04.04.006; 22.01.01.010; 20.05.01.009--Not Available
Guillain-Barre syndrome17.09.01.001; 10.04.10.005; 11.07.01.001--
Blood urine present13.13.02.002--Not Available
Headache17.14.01.001--
Herpes virus infection11.05.02.008--Not Available
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Lung infiltration22.01.02.004--Not Available
Lymphopenia01.02.02.002--Not Available
Mucosal inflammation08.01.06.002--Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neck pain15.03.04.009--
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